Results 1 to 10 of about 188,181 (263)

Early risk assessment for COVID-19 patients from emergency department data using machine learning

Scientific Reports, 2021
Since its emergence in late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with more than 55 million reported cases and 1.3 million estimated deaths worldwide.
Frank S. Heldt, Marcela P. Vizcaychipi, Sophie Peacock, Mattia Cinelli, Lachlan McLachlan, Fernando Andreotti, Stojan Jovanović, Robert Dürichen, Nadezda Lipunova, Robert A. Fletcher, Anne Hancock, Alex McCarthy, Richard A. Pointon, Alexander Brown, James Eaton, Roberto Liddi, Lucy Mackillop, Lionel Tarassenko, Rabia T. Khan   +18 more
doaj   +1 more source

Defining the therapeutic reference range for cariprazine

European Psychiatry, 2023
Introduction According to the Consensus Guideline, the “therapeutic reference range” (TRR) defines ranges of drug blood concentrations that specify a lower limit below which a drug-induced therapeutic response is unlikely to occur and an upper limit ...
M. Kapás, A. Horváth, D. Djuric, R. Csehi, Á. Barabássy   +4 more
doaj   +1 more source

A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study

Arthritis Research & Therapy, 2022
Background Publications suggest immunomodulation co-therapy improves responder rates in uncontrolled/refractory gout patients undergoing pegloticase treatment.
John K. Botson, John R. P. Tesser, Ralph Bennett, Howard M. Kenney, Paul M. Peloso, Katie Obermeyer, Yang Song, Brian LaMoreaux, Lin Zhao, Yan Xin, Jason Chamberlain, Srini Ramanathan, Michael E. Weinblatt, Jeff Peterson   +13 more
doaj   +1 more source

Similarity-based prediction of ejection fraction in heart failure patients

Informatics in Medicine Unlocked, 2022
Biomedical research is increasingly employing real world evidence (RWE) to foster discoveries of novel clinical phenotypes and to better characterize long term effect of medical treatments.
Jamie Wallis, Andres Azqueta-Gavaldon, Thanusha Ananthakumar, Robert Dürichen, Luca Albergante   +4 more
doaj   +1 more source

Risk factors for exacerbations and pneumonia in patients with chronic obstructive pulmonary disease: a pooled analysis

Respiratory Research, 2020
Background Patients with chronic obstructive pulmonary disease (COPD) are at risk of exacerbations and pneumonia; how the risk factors interact is unclear.
Benjamin F. Hartley, Neil C. Barnes, Sally Lettis, Chris H. Compton, Alberto Papi, Paul Jones   +5 more
doaj   +1 more source

Safety during polypharmacy: A post-hoc analysis examining the safety profile of cariprazine with other antipsychotics in the cross-titration phase

European Psychiatry, 2021
Introduction Although monotherapy is preferable, in every day clinical practice polypharmacy is often unavoidable due to the need of treatment enhancement or cross-titration phases with shorter or longer overlaps of two or more drugs.
G. Vass, Á. Barabássy, I. Laszlovszky, B. Sebe, Z.B. Dombi, B. Szatmári, G. Németh   +6 more
doaj   +1 more source

The effect of cariprazine on patient engagement: Post-hoc analysis of a phase 3 study in patients with predominant negative symptoms of schizophrenia

European Psychiatry, 2021
Introduction Motivation deficit is a significant aspect of lack of improvement in patients with schizophrenia especially with predominant negative symptoms (PNS).
I. Laszlovszky, Z.B. Dombi, Á. Balogh, Á. Barabássy, G. Vass, B. Szatmári, G. Németh   +6 more
doaj   +1 more source

Application of the deterministical and stochastical geostatistical methods in petrophysical modelling - a case study of Upper Pannonian reservoir in Sava Depression

Geologia Croatica, 2017
Deterministic methods are still widely used for reservoir characterization and modelling. The result of such methods is only one solution. It is clear that our knowledge about the subsurface is uncertain.
Kristina Novak Zelenika, Renata Vidaček, Tomislav Ilijaš, Petar Pavić   +3 more
doaj   +1 more source

Automated System for Capture and Detection of Nucleic Acids

BioTechniques, 1999
A fully automated nucleic acid analysis system is described, which offers positive sample identification, improved sensitivity and reduced user interaction compared to conventional techniques.
A. Brown, A.A. Akinsanya, S.J. Barker, M. Brophy, A.K. Dobb, S.M. Doyle, I.R. Hudson, S.J. Minter, M.J. Wraith, J.D. Oultram   +9 more
doaj   +1 more source

An assessment of nicotine pharmacokinetics and subjective effects of the pulze heated tobacco system compared with cigarettes

Scientific Reports, 2023
Nicotine delivery and subjective effects are determinants of the ability of potentially less harmful tobacco products such as heated tobacco products (HTPs) to support adult smokers in switching away from cigarettes, and therefore to support tobacco harm
Simon McDermott, Kerstin Reichmann, Elizabeth Mason, Ian M. Fearon, Grant O’Connell, Thomas Nahde   +5 more
doaj   +1 more source