Results 101 to 110 of about 499,359 (346)

Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturity

Frontiers in Genome Editing
Porcine reproductive and respiratory syndrome (PRRS) is one of the world’s most persistent viral pig diseases, with a significant economic impact on the pig industry.
Clint Nesbitt, Lucina Galina Pantoja, Benjamin Beaton, Ching-Yi Chen, Matt Culbertson, Perry Harms, Justin Holl, Andrzej Sosnicki, Srinu Reddy, Marisa Rotolo, Elena Rice   +10 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Evaluation of high-nicotine oral products shows potential to reduce tobacco-related harm by offering satisfying alternatives

Scientific Reports
Modern oral nicotine delivery (MOND) offers potentially reduced harm nicotine delivery for adult smokers who do not wish to quit. Most clinical studies to date have characterised MOND with lower nicotine content, therefore, this study aimed to assess ...
Fiona Chapman, Ruby Morrissey, Simon McDermott, Xavier Cahours, Thomas Verron, Victoria Taverner, Matthew Stevenson, Thomas Nahde   +7 more
doaj   +1 more source

Eclipsing Binaries in the OGLE Variable Star Catalogs.V. Long-Period Beta Lyrae-type Systems in the Small Magellanic Cloud and the PLC-beta Relation

, 2000
Thirty eight long-period (P>10 days), apparently contact binary stars discovered by the OGLE-II project in the SMC appear to be Beta Lyrae-type systems with ellipsoidal variations of the cool components dominating over eclipse effects in the systemic ...
Carla Maceroni, De Greve J. P., Harmanec P., Paczynski B., Robertson J. A., Rucinski S. M., Slavek M. Rucinski, Udalski A., Udalski A., Udalski A.   +9 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Best Approximation from the Kuhn-Tucker Set of Composite Monotone Inclusions [PDF]

, 2014
Kuhn-Tucker points play a fundamental role in the analysis and the numerical solution of monotone inclusion problems, providing in particular both primal and dual solutions.
Abdullah Alotaibi, King Abdulaziz, Naseer Shahzad, Patrick L. Combettes   +3 more
core  

The Portevin-Le Chatelier effect in the Continuous Time Random Walk framework

, 2006
We present a continuous time random walk model for the Portevin-Le Chatelier (PLC) effect.
A. Sarkar, Anna, Barat, Barvik, Berkowitz, Bharathi, Chihab, Hahner, Klafter, Kubin, Lebyodkin, Louche, McCoCormick, McCormick, Mertens, Metzler, Minc, Montroll, P. Barat, Portevin, Scafetta, Scafetta, Shabadi, Shlesinger, van den Beukel, Zaiser, Zhang, Zumofen   +27 more
core   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source