Results 81 to 90 of about 158,014 (315)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Molecular Profiling of Circulating Tumour Cells and Circulating Tumour DNA: Complementary Insights from a Single Blood Sample Utilising the Parsortix^® System

Current Issues in Molecular Biology
The study of molecular drivers of cancer is an area of rapid growth and has led to the development of targeted treatments, significantly improving patient outcomes in many cancer types.
Gabrielle Wishart, Amy Templeman, Francesca Hendry, Karen Miller, Anne-Sophie Pailhes-Jimenez   +4 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Evaluation of high-nicotine oral products shows potential to reduce tobacco-related harm by offering satisfying alternatives

Scientific Reports
Modern oral nicotine delivery (MOND) offers potentially reduced harm nicotine delivery for adult smokers who do not wish to quit. Most clinical studies to date have characterised MOND with lower nicotine content, therefore, this study aimed to assess ...
Fiona Chapman, Ruby Morrissey, Simon McDermott, Xavier Cahours, Thomas Verron, Victoria Taverner, Matthew Stevenson, Thomas Nahde   +7 more
doaj   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Sörfőzés során alkalmazott adalékanyagok mérésének rekonstrukciója PLC-s felügyelettel [PDF]

, 2013
Dolgozatomban egy nemzetközileg ismert sörgyártó vállalat adalékanyag adagoló rendszerének rekonstrukcióját kísértem végig. Ismertetem az előző rendszer hiányosságait, javaslatokat teszek ezek kiküszöbölésére.
Tanyi, Zsuzsanna
core  

Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturity

Frontiers in Genome Editing
Porcine reproductive and respiratory syndrome (PRRS) is one of the world’s most persistent viral pig diseases, with a significant economic impact on the pig industry.
Clint Nesbitt, Lucina Galina Pantoja, Benjamin Beaton, Ching-Yi Chen, Matt Culbertson, Perry Harms, Justin Holl, Andrzej Sosnicki, Srinu Reddy, Marisa Rotolo, Elena Rice   +10 more
doaj   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

PLC redundancia kialakítása meglévő Profibus hálózaton [PDF]

, 2017
A dolgozat témája, egy redundáns PLC rendszer kialakításáról szól. Egy már meglévő Profibus hálózaton, az eszközök elérhetőségének megbízhatóságát tovább növeljük redundancia kialakításával.gjVillamosmérnökBSc ...
Hritz, István
core  

Development of PLC-Based Automated Virtual Cooking Machine [PDF]

, 2023
This thesis presents a comprehensive study on the development and implementation of an automated cooking machine based on PLC, with the objective of enhancing cooking efficiency and convenience.
Md Nayeem, Hossain
core