Results 71 to 80 of about 158,014 (315)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

PLC vezérlésű mérőberendezés fejlesztése szabványos termék teszteléshez [PDF]

, 2014
PLC vezérlésű vizsgáló berendezés tervezése, és megépítése, villamos meghajtású forgómotorok, illetve egyéb típusú elektromos fogyasztók sorozatgyártott késztermékekbe való beépítésük után elvégzendő terheléses élettartam vizsgálathoz.gjVillamosmérnök ...
Pálocska, Máté
core  

Development and Implementation of PLC-Controlled Virtual Car Washing Station [PDF]

, 2020
The main objective of this thesis is to develop a virtual car washing station by using PLC (Programmable Logic Controllers). The washing station provides facility of four stages that are soap wash, brushing, clean water wash and drying.
Hussain, Muhammad
core  

The Role of Partial Agonists and Specifically Cariprazine in Dual Disorders

European Psychiatry
Introduction The treatment of dual disorders, the co-occurrence of a major psychiatric disorder and a substance use disorder, represents a great challenge. Recent articles recommend antipsychotics with a dopamine partial agonism as first line treatment
Á. Barabássy, Z. B. Dombi, R. Csehi, D. Djuric, G. Németh   +4 more
doaj   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

A systematic literature review and network meta-analysis feasibility study to assess the comparative efficacy and comparative effectiveness of pneumococcal conjugate vaccines

Human Vaccines & Immunotherapeutics, 2019
Background: No head-to-head studies are currently available comparing pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with 13-valent pneumococcal conjugate vaccine (PCV-13).
Ashleigh McGirr, Shehzad M. Iqbal, Patricia Izurieta, Carla Talarico, Janneke Luijken, Josefine Redig, Rachel S. Newson   +6 more
doaj   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Implementation of PLC-controlled tray drier model [PDF]

, 2011
Implementation of PLC-controlled tray drier model, development of control, web-visualization and touch screen processing programs.
Djiedeu Toko, Patrice
core  

A patient safety knowledge graph supporting vaccine product development

BMC Medical Informatics and Decision Making
Background Knowledge graphs are well-suited for modeling complex, unstructured, and multi-source data and facilitating their analysis. During the COVID-19 pandemic, adverse event data were integrated into a knowledge graph to support vaccine safety ...
Andrew M. Simms, Anshul Kanakia, Muhammad Sipra, Bhaskar Dutta, Noel Southall   +4 more
doaj   +1 more source

Development of a bedside tool to predict the probability of drug-resistant pathogens among hospitalized adult patients with gram-negative infections

BMC Infectious Diseases, 2019
Background We developed a clinical bedside tool to simultaneously estimate the probabilities of third-generation cephalosporin-resistant Enterobacteriaceae (3GC-R), carbapenem-resistant Enterobacteriaceae (CRE), and multidrug-resistant Pseudomonas ...
Thomas P. Lodise, Nicole Gidaya Bonine, Jiatao Michael Ye, Henry J. Folse, Patrick Gillard   +4 more
doaj   +1 more source