Results 191 to 200 of about 194,741 (300)

How Much to Sell and When: Optimal Staged Divestiture of Patent‐Linked Royalty Claims Under Risk, Illiquidity, and Finite Horizon

Managerial and Decision Economics, EarlyView.
ABSTRACT Patent owners can sell a royalty interest in stages rather than all at once. This paper asks how much to sell now when claim values are uncertain, buyers are costly to reach, and patent expiry limits the time available. A decision model produces sale schedules that adjust to current value, the share retained, and time remaining.
Andreas Peters
wiley   +1 more source

Metabolic Reprogramming-Targeted Therapeutic Strategies in Primary Liver Cancer: A Bibliometric and Visualized Analysis. [PDF]

J Hepatocell Carcinoma
Yang Q, Yu L, Peng Y, Yuan Q, Fan N, Wang G.   +5 more
europepmc   +1 more source

Weak SLP-76/PLC-γ1 interaction fine-tunes T cell receptor signal strength to optimize T cell responsiveness. [PDF]

Nat Commun
Yamane H, Wada J, Stassenko EN, Convertino ND, Lee ME, Vacchio MS, Li W, Livak F, Rathnayake UM, Balagopalan L, Chari R, Hagenau H, Awasthi P, McGavern DB, Bosselut R, Samelson LE.   +15 more
europepmc   +1 more source

The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta‐Analysis

Movement Disorders, EarlyView.
Abstract Background Variants in GBA1 are important genetic risk factors for synucleinopathies, including Parkinson's disease (PD). Although several GBA1 variants are established risk or severity modifiers, the role of the p.E427K variant remains unclear.
Leah V. Chifamba, Sitki Cem Parlar, Emma N. Somerville, Lang Liu, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Jennifer A. Ruskey, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Irina Miliukhina, Lior Greenbaum, Sharon Hassin‐Baer, Orly Goldstein, Mandy Radefeldt, Peter Bauer, Christian Beetz, Allison A. Dilliott, James C. Beck, Konstantin Senkevich, ROPAD Study Group, The Parkinson's Foundation PD GENEration Study, Christine Klein, Roy N. Alcalay, Ziv Gan‐Or   +30 more
wiley   +1 more source

Endogenous tracking reveals paralog-specific targets for phosphatidic acid generation during phospholipase C signaling in living cells. [PDF]

J Biol Chem
Weckerly CC, Murtagh OL, Swayhoover T, Pemberton JG, Hsu KL, Hammond GRV.   +5 more
europepmc   +1 more source

Rare‐Variant Burden Analysis of Dystonia Genes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Dystonia frequently coexists with Parkinson's disease (PD), yet the extent of genetic overlap remains insufficiently explored. Objective The aim was to examine whether rare variants in dystonia‐related genes are associated with PD or early‐onset PD (EOPD).
Sajanth Kanagasingam, Sitki Cem Parlar, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +4 more
wiley   +1 more source

Optimizing the Cascade Deep Neural Network Parameters Using an Egret Swarm Optimisation Algorithm: An Application to PID Tuning for the AVR with Shallow Controller. [PDF]

Biomimetics (Basel)
Elhawat M, Altınkaya H.
europepmc   +1 more source

Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1‐Associated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making.
Evridiki Asimakidou, Micol Avenali, Jan O. Aasly, Mitra Afshari, Roy N. Alcalay, Sharlet Anderson, Carlo Alberto Artusi, Bryan Bernard, Marco Bozzali, Susan Bressman, Giovanna Calandra‐Buonaura, Francesco Cavallieri, Roberto Cilia, Jean‐Christoph Corvol, Antoniangela Cocco, Rob M.A. de Bie, Debra Ehrlich, Roberto Eleopra, Thomas Foltynie, Alessio Di Fonzo, Giulia Giannini, Christopher Goetz, Deborah Hall, Joohi Jimenez‐Shahed, Leonardo Lopiano, Vanessa Lythe, Maria Chiara Malaguti, Francesca Mameli, Graziella Mangone, Karen Marder, M. Maral Mouradian, Augusto Rini, Luisa Sambati, Rachel Saunders‐Pullman, Vicki Lynn Shanker, Francesca Spagnolo, Marie‐Laure Welter, Roberta Zangaglia, Gian Pal, Enza Maria Valente, PARKNET Study Group, Giada Cuconato, Ilaria Palmieri, Alberto Imarisio, Pierfrancesco Mitrotti, Francesca Valentino, Claudio Pacchetti, Gabriele Imbalzano, Claudia Ledda, Silvia Gallo, Pietro Cortelli, Luca Baldelli, Ilaria Cani, Raffaella Minardi, Valerio Carelli, Franco Valzania, Edoardo Monfrini, Filippo Cogiamanian, Chiara Longo, Fabiana Colucci, Luigi M. Romito, Marco Liccari   +61 more
wiley   +1 more source