Results 211 to 220 of about 194,741 (300)

Monomeric C-reactive protein potentiates microglia-mediated neuroinflammation in Alzheimer's disease via the PLC-PKC-MAPK-NF-κB pathway. [PDF]

J Biol Chem
Zhang J, Zhu Y, Zhang Q, Dai Y, Liu H, Shi J, Jiang Y, Chen Q.   +7 more
europepmc   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Acetylcholine and Prolactin, Other Factors in Breast Cancer. [PDF]

Int J Mol Sci
Calaf GM, Andrade-Madrigal C, Crispin LA, Miranda VH, Aguayo F.   +4 more
europepmc   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Minimally Invasive Approach to Multiligament Knee Reconstruction: Arthroscopic PCL and PLC With Percutaneous LCL Reconstruction. [PDF]

Video J Sports Med
Philippe C, Alayane A, Jacotti S, Sonnery-Cottet V, Mouarbes D, Pailhe R, Cavaignac E.   +6 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Early life adversity shapes neural and behavioural responses to oxytocin during altruistic decision-making. [PDF]

Transl Psychiatry
Marsh N, Jeske V, Babasiz M, Herscheid A, Kreuder AK, Stirnberg R, Stoecker T, Marsh AA, Schultz J, Hurlemann R.   +9 more
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Authentication of <i>Puerariae</i> <i>Lobatae Radix</i> and Its Adulterant <i>Puerariae Lobatae Caulis</i> via Digital ID Technology. [PDF]

Foods
Ma T, Jia Z, Wang X, Wu H, Lin Y, Li H, Chen J, Cheng X.   +7 more
europepmc   +1 more source