Results 71 to 80 of about 210,488 (345)

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Evaluation of high-nicotine oral products shows potential to reduce tobacco-related harm by offering satisfying alternatives

Scientific Reports
Modern oral nicotine delivery (MOND) offers potentially reduced harm nicotine delivery for adult smokers who do not wish to quit. Most clinical studies to date have characterised MOND with lower nicotine content, therefore, this study aimed to assess ...
Fiona Chapman, Ruby Morrissey, Simon McDermott, Xavier Cahours, Thomas Verron, Victoria Taverner, Matthew Stevenson, Thomas Nahde   +7 more
doaj   +1 more source

Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturity

Frontiers in Genome Editing
Porcine reproductive and respiratory syndrome (PRRS) is one of the world’s most persistent viral pig diseases, with a significant economic impact on the pig industry.
Clint Nesbitt, Lucina Galina Pantoja, Benjamin Beaton, Ching-Yi Chen, Matt Culbertson, Perry Harms, Justin Holl, Andrzej Sosnicki, Srinu Reddy, Marisa Rotolo, Elena Rice   +10 more
doaj   +1 more source

Development of a bedside tool to predict the probability of drug-resistant pathogens among hospitalized adult patients with gram-negative infections

BMC Infectious Diseases, 2019
Background We developed a clinical bedside tool to simultaneously estimate the probabilities of third-generation cephalosporin-resistant Enterobacteriaceae (3GC-R), carbapenem-resistant Enterobacteriaceae (CRE), and multidrug-resistant Pseudomonas ...
Thomas P. Lodise, Nicole Gidaya Bonine, Jiatao Michael Ye, Henry J. Folse, Patrick Gillard   +4 more
doaj   +1 more source

Practical PLC Applications

Queen Arwa University Journal, 2010
تعتبر انظمة التحكم المبرمجة من الاجهزة الشائعة الاستخدام في العمليات الصناعية بسبب استجابتها السريعة وخصائصها الاخرى التي تميزها عن الاجهزة الاخرى. وقد تم في هذا البحث شرح ووصف اجهزة التحكم المبرمجة اضافة الى تنفيذ ثلاثة انظمة عملية باستخدام انظمة التحكم المبرمجة وهي: عملية التثقيب وعملية التحويل والمصعد الكهربائي ونلاحظ من خلال تنفيذ ...
openaire   +1 more source

Quantifying Additive Manufacturing Vapor Plumes Using Laser‐Induced Breakdown Spectroscopy, Synchrotron X‐Ray Radiography and Simulations

Advanced Science, EarlyView.
This study presents a novel in situ laser‐induced breakdown spectroscopy system for monitoring metal vapors produced by the intense laser‐metal interactions in laser powder bed fusion additive manufacturing and laser welding. The insights from this new technique reveal changes in alloy compositions and provide the first in situ validation of multi ...
Anna C. M. Getley, Samy Hocine, Junji Shinjo, Chinnapat Panwisawas, Marta Majkut, Alexander Rack, Peter D. Lee, Michael Towrie, Chu Lun Alex Leung   +8 more
wiley   +1 more source

Molecular Profiling of Circulating Tumour Cells and Circulating Tumour DNA: Complementary Insights from a Single Blood Sample Utilising the Parsortix^® System

Current Issues in Molecular Biology
The study of molecular drivers of cancer is an area of rapid growth and has led to the development of targeted treatments, significantly improving patient outcomes in many cancer types.
Gabrielle Wishart, Amy Templeman, Francesca Hendry, Karen Miller, Anne-Sophie Pailhes-Jimenez   +4 more
doaj   +1 more source

Water‐Efficient Smart Drip Irrigation Enabled by a Low‐Power and High‐Efficiency Flexible Electromagnetic Actuator

Advanced Science, EarlyView.
Water scarcity poses a critical threat to global food security. A low‐power, flexible electromagnetic actuator is presented for smart drip irrigation systems. The device achieves precise, wide‐range flow modulation (0.05–5.8 mL/min) in response to real‐time plant demands, reducing water consumption compared to conventional flood irrigation.
Duo Chen, Xubin Zhu, Minwei Zhang, Kerui Li, Qinghong Zhang, Yaogang Li, Chengyi Hou, Hongzhi Wang   +7 more
wiley   +1 more source