Results 31 to 40 of about 271,634 (314)

Provider and Parent Perspectives on Prioritizing the “Asking and Monitoring” Pediatric Cancer Psychosocial Standards of Care

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families (“Standards”) are evidence‐based guidelines for psychosocial care in pediatric oncology. Care related to the three “Asking and Monitoring” Standards—Assessment of Psychosocial Needs, Assessment of Financial Needs, and Monitoring Neurocognitive Problems ...
Julia B. Tager   +8 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Pleasure In Leisure

open access: yes, 2015
British Photographer Matthew Murray has just released a new book, Pleasure in Leisure, published by Cafe Royal Books in an Edition of 200. His hilarious and well-seen capture of humanity at leisure around the globe shows us that humor is universal.
Murray, Matthew
core   +2 more sources

الاختيارات الفقهية للحاكم الجشمي فى تفسيره التهذيب (بعض مسائل النكاح نموذجاً). [PDF]

open access: yesمجلة کلية الآداب. جامعة أسوان
" بسم الله الرحمن الرحيم"الحمد لله حمداً يوافى نعمه , ويكافؤ مزيده ، وأشهد أن لا إله إلا الله وحده لا شريك له، وأشهد أن محمدًا عبد الله ورسوله ، صل اللهم وسلم وبارك عليه. وبعد..فيهدف هذا البحث إلى بيان عناية أهل العلم عمومًا, والمتخصصين من الفقهاء خصوصاً
محمد محمد عبد الصمد محمد إبراهيم   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Aesthetics and Evolution

open access: yesAisthesis, 2013
Starting from the assumption that art, being a pervasive human behaviour across time and  space, must have an evolutionary adaptive purpose, the Author claims in this paper that  art making has evolved as a behaviour that serves to bind individuals ...
Nancy Aiken
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

The Relation between Sensory Perception,Perfection and Pleasure with Beauty in Christian Wolff's Aesthetics [PDF]

open access: yesPizhūhish/hā-yi Falsafī- Kalāmī, 2018
Christian Wolff's view regarding sensory perception – which is formed on a Leibnizian framework – forms the base of his aesthetics. He explains the concept of perfection and pleasure according to the clear but disordered essence of sensory perception ...
Davoud Mirzaei   +2 more
doaj   +1 more source

How Damsels Love: The Transgressive Pleasure of Romance

open access: yesNew Horizons in English Studies, 2021
In this article, I look at contemporary romances as a source of transgressive pleasure that may inspire its audience to reject patriarchy. I focus solely on romances between a man and a woman with emphasis on the psychological dimension of the female ...
Renata E. Ntelia
doaj   +1 more source

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