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الاختيارات الفقهية للحاكم الجشمي فى تفسيره التهذيب (بعض مسائل النكاح نموذجاً). [PDF]

مجلة کلية الآداب. جامعة أسوان
" بسم الله الرحمن الرحيم"الحمد لله حمداً يوافى نعمه , ويكافؤ مزيده ، وأشهد أن لا إله إلا الله وحده لا شريك له، وأشهد أن محمدًا عبد الله ورسوله ، صل اللهم وسلم وبارك عليه. وبعد..فيهدف هذا البحث إلى بيان عناية أهل العلم عمومًا, والمتخصصين من الفقهاء خصوصاً
محمد محمد عبد الصمد محمد إبراهيم, أحمد حسن, وجيه عبد القادر شعبان الخرشى   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

NEUTRALITY AND PLEASURE

Economics and Philosophy, 2007
John Broome's ground-breaking Weighing Lives makes precise, and supplies arguments previously lacking for, several views which for centuries have been central to the utilitarian tradition. In gratitude for his enlightening arguments, I shall repay him in this paper by showing how he could make things easier for himself by denying neutrality and ...
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Vérité et volupté chez Lamartine

Revue Italienne d'Etudes Françaises, 2020
The concept of truth is central in Lamartine’s work and it illustrates the renewal of lyricism in the 19th century. It is a key of his poetic inspiration and his relation to God and to the world. It is also part of his mystical conception of love.
Romain Jalabert
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

SEXUALITY IN A CONTEXT OF SPECULATIVE POSTHUMANISM: HUMAN-POSTHUMAN RUPTURES AND DISCONNECTIONS

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2019
In this article human-posthuman ruptures and disconnections both in comprehension and in practices, as well as the possibility of epistemological contingency contemporaneously are investigated.
Nataliia V. Zahurska
doaj   +1 more source

Paradoxes of Pain: A Dialogue between Plato and Contemporary Phenomenology

Azafea: Revista de Filosofía, 2020
The paper presents a dialogue, between contemporary phenomenology and Plato, on the nature and complexity of pain. Taking as a departure point D. Leder’s article «The experiential paradoxes of pain», the article delves into the essentially liminal ...
Bernat Morales Torres
doaj   +1 more source