Results 41 to 50 of about 1,298,153 (304)

Vérité et volupté chez Lamartine

open access: yesRevue Italienne d'Etudes Françaises, 2020
The concept of truth is central in Lamartine’s work and it illustrates the renewal of lyricism in the 19th century. It is a key of his poetic inspiration and his relation to God and to the world. It is also part of his mystical conception of love.
Romain Jalabert
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Pleasure as self-discovery [PDF]

open access: yes, 2012
This paper uses readings of two classic autobiographies, Edmund Gosse’s Father & Son and John Stuart Mill’s Autobiography, to develop a distinctive answer to an old and central question in value theory: What role is played by pleasure in the most ...
Clark, Samuel
core   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

SEXUALITY IN A CONTEXT OF SPECULATIVE POSTHUMANISM: HUMAN-POSTHUMAN RUPTURES AND DISCONNECTIONS

open access: yesВісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2019
In this article human-posthuman ruptures and disconnections both in comprehension and in practices, as well as the possibility of epistemological contingency contemporaneously are investigated.
Nataliia V. Zahurska
doaj   +1 more source

Paradoxes of Pain: A Dialogue between Plato and Contemporary Phenomenology

open access: yesAzafea: Revista de Filosofía, 2020
The paper presents a dialogue, between contemporary phenomenology and Plato, on the nature and complexity of pain. Taking as a departure point D. Leder’s article «The experiential paradoxes of pain», the article delves into the essentially liminal ...
Bernat Morales Torres
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

'Pleasure too often Repeated': Aldous Huxley's Modernity [PDF]

open access: yes, 2013
Chapter NYP. EUP allows authors to retain the the right to post a pre-publication version of the contribution on their personal or departmental web page or Institutional Repository or in a disciplinary repository such as the Humanities Research Network ...
SHIACH, ME
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz   +25 more
wiley   +1 more source

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