Results 111 to 120 of about 23,583 (245)

Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence—The Protective Effect of Valsartan

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Calcineurin inhibitors (CNI) such as tacrolimus (Tac) are the first‐line treatment to prevent transplant rejection. However, CNI have adverse effects on blood vessels and renal function, which may be linked to cellular senescence. Valsartan, a common angiotensin II type 1 receptor (AT1R) blocker, exhibits anti‐senescence properties.
Lingyan Fei, Xiaohua Wang, Lingyi Kong, Tianjiao Cui, Pratik H. Khedkar, Yunxiu Xiang, Dongliang Zhao, Junxuan Fang, Yulin Liang, Yangyang Zhang, Nan Xu, Xingyu Qiu, Liang Zhao, Gensheng Zhang, Yan Lei, Chun Tang, Kongyang Ma, Liwei Lu, Jin Wei, En Yin Lai, Pontus B. Persson, Andreas Patzak, Zhihua Zheng, Shan Jiang   +23 more
wiley   +1 more source

A respiratory signature of disease progression in the Pompe rat. [PDF]

J Neurophysiol
Mickle AR, Rana S, Benevides ES, Byrne BJ, Fuller DD, Dale EA.   +5 more
europepmc   +1 more source

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO2 chemoreflex is a critical component of this neural circuitry, as defects in these sensors cause hypoventilation syndromes, which are typically difficult to manage ...
Silvia Cardani, Tara A. Janes, Ryaad Asif, Silvia Pagliardini   +3 more
wiley   +1 more source

Correlation Between Body Plethysmography and Impulse Oscillometry Across Obstructive and Restrictive Lung Diseases: Evidence from an Adult Pilot Study Cohort. [PDF]

Diagnostics (Basel)
Budin EC, Vladimir I, Râjnoveanu RM, Huțanu D, Vultur MA, Mărginean C, Muntean ST, Ianoși ES, Jimborean G, Cotoi OS.   +9 more
europepmc   +1 more source

Nintedanib Lacks Efficacy in a Spirometry‐Confirmed and Bleomycin‐Induced Mouse Model of Idiopathic Pulmonary Fibrosis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three independent treatment intervention studies in the single‐dose bleomycin (BLEO) mouse model of IPF.
Jamal Bousamaki, Grzegorz Maciag, Asbjørn Graver Petersen, Stefanie H. Korntner, Stine Marie Jansen, Susanne E. Pors, Linn Salto Mamsen, Silas A. Rasmussen, Casper Gravesen Salinas, Louise Humle Kruse, Michael Feigh, Ulf Simonsen, Henrik H. Hansen   +12 more
wiley   +1 more source

Rest‐Activity Rhythms and Cognition in Older Adults With and Without Insomnia

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Insomnia is associated with risk for cognitive deficits. However, the literature assessing cognitive impairments in insomnia is replete with conflicting findings; it is unclear whether individuals with insomnia exhibit impaired cognition or whether specific sleep features consistently predict cognitive performance in insomnia.
Miranda G. Chappel‐Farley, Zhiwei Zhao, Christine W. Johnston, Shuo Chen, Avelino C. Verceles, Valerie E. Rogers, Daniel J. Buysse, Emerson M. Wickwire, Kristine A. Wilckens   +8 more
wiley   +1 more source

Respiratory morbidity 6 to 12 months after mechanical ventilation for life-threatening respiratory syncytial virus infection. [PDF]

ERJ Open Res
Vrijlandt EJLE, Wolthuis DW, Renken NW, Sijmons AF, Koppelman GH, Kneyber MCJ.   +5 more
europepmc   +1 more source

Diminazene Aceturate Ameliorates Hypertension‐Induced Cognitive Impairment by Disrupting the CCN1–Integrin αvβ6–TGF‐β Axis and Preserving Mitochondrial Integrity

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Hypertension drives cognitive decline through a previously unrecognized CCN1–integrin αvβ6–TGF‐β signaling axis that culminates in mitochondrial dysfunction and hippocampal neuronal injury. In this pathway, angiotensin II induces CCN1 upregulation, which activates αvβ6 integrin‐mediated release of latent TGF‐β, triggering SMAD2/3 phosphorylation and ...
Xufang Huo, Zhenyu Wu, Xinqian Zhou, Yuancheng Zhou, Jiming Liu, Hongbing Li, Yijiu Wu, You Huang, Guangling Feng, Xiaolin Hu, Qingfan Zeng   +10 more
wiley   +1 more source

Differential sensitivity of impedance plethysmography and photoplethysmography sensors to temperature-induced peripheral vasoconstriction. [PDF]

Sci Rep
Jung S, Thomson S, Pantelopoulos A, Sunden L, Richards P, Patel S, Sheng S.   +6 more
europepmc   +1 more source

Methotrexate Therapy in Juvenile Idiopathic Arthritis: No Clinically Relevant Pulmonary Impairment but Frequent Transient Liver Enzyme Elevations in a Longitudinal Single‐Center Pediatric Cohort of 274 Children Over 30 Years

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective Methotrexate (MTX) is a cornerstone in treating juvenile idiopathic arthritis (JIA). The long‐term impact of MTX, particularly on pulmonary and liver function, remains a concern. We longitudinally examined the effects of MTX on pulmonary and hepatic function in the largest reported cohort to date.
Janosch Weßling, Christoph Leiskau, Frank Dressler, Christian Klemann   +3 more
wiley   +1 more source