Results 41 to 50 of about 58,831 (274)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Clinical Value of Pleural Effusion and Serum MMP-3 and CYFRA21-1 Combined with ADA in Differential Diagnosis of Pleural Exudative Effusion

Emergency Medicine International, 2022
Objective. The aim of the study is to investigate the clinical value of matrix metalloproteinases-3 (MMP-3) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) combined with adenosine deaminase (ADA) in pleural effusion and serum in benign and malignant
Zhiyang Xu, Jun Guan, Jianxin Xu, Jiahua Tu, Jiangdong Cheng   +4 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Gas Biopsy of Pleural Effusion to Diagnose Lung Cancer by Mass Spectrometry. [PDF]

MedComm (2020)
HS‐SPME–GC–MS profiling of pleural effusion revealed distinct volatile metabolic features between lung cancer‐associated malignant pleural effusion and benign pleural effusion. Cross‐matrix integration with paired lung cancer tissues identified hexanal as the only shared differential VOC.
Liu W, Qi J, Chu Y, Zhou J, Liu Y, Ke L, Zheng X, Lu Y, Ge D, Chu Y, Wang H.   +10 more
europepmc   +2 more sources

Diagnostic value of procalcitonin in pleural effusion

Egyptian Journal of Chest Disease and Tuberculosis, 2020
Background A wide range of diseases can cause pleural effusion. Its diagnosis and management remain a clinical challenge, bearing a significant cost to both patients and health care system.
Abdelsadek H Al-Aarag, Shuzan A Mohammed, Hoda Y Ibrahim, Osama I Mohammad   +3 more
doaj   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Diagnostic value of calprotectin in differentiation between benign and malignant pleural effusion

The Egyptian Journal of Bronchology, 2019
Background Pleural effusion can arise as a result of more than 50 recognized causes and the differentiation between benign and malignant origin of the fluid is still a diagnostic challenge.
Omar M. Mohammed, Kamel M. Hussein, Abdelgawad E. Ramadan, Gouda T. Mahmoud, Marwa El-Sayed El-Naggar, Nor Eldein Z. Gaber   +5 more
doaj   +1 more source

Managing malignant pleural effusion

Cleveland Clinic Journal of Medicine, 2019
Malignant pleural effusion can be managed in different ways, including clinical observation, thoracentesis, placement of an indwelling pleural catheter, and chemical pleurodesis. The optimal strategy depends on a variety of clinical factors. This article uses cases to illustrate the rationale for determining the best approach in different situations.
Ali Saeed, Wahla, Mateen, Uzbeck, Yaser Abu, El Sameed, Zaid, Zoumot   +3 more
openaire   +2 more sources

Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study

, 2014
Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection.
Jonny Peter, Greg Symons, Meldau, Richard, Symons, Greg, Calligaro, Greg, van Zyl-Smit, Richard, Gina Ntombenhle, Peter, Jonny, Hoosain Khalfey, Keertan Dheda, Grant Theron, Greg Calligaro, Brian Allwood, Anke Binder, Allwood, Brian, Govender, Ureshnie, Ntombenhle, Gina, Ureshnie Govender, Dheda, Keertan, Theron, Grant, Khalfey, Hoosain, Richard Meldau, Richard van Zyl-Smit, Binder, Anke   +23 more
core   +1 more source

Treatment of malignant pleural effusion

Journal of Visualized Surgery, 2018
Malignant pleural effusion (MPE) is a very disabling condition that often affects patients with advanced neoplasm. Conservative approach, repeated thoracentesis, pleurodesis and use of indwelling pleural catheters (IPC) are the main methods to deal with this condition.
Ricardo Mingarini, Terra, Alberto Jorge Monteiro, Dela Vega   +1 more
openaire   +3 more sources