Results 81 to 90 of about 314,927 (315)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

The Role of 18F-FDG PET/CT Integrated Imaging in Distinguishing Malignant from Benign Pleural Effusion

PLoS ONE, 2016
Objective The aim of our study was to evaluate the role of 18F-FDG PET/CT integrated imaging in differentiating malignant from benign pleural effusion.
Yajuan Sun, Hongjuan Yu, Jingquan Ma, Peiou Lu   +3 more
semanticscholar   +1 more source

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases—An update

British Journal of Clinical Pharmacology, EarlyView.
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel, Adeline Benis, Philippe Bonniaud, Jean‐Luc Faillie, Aurélie Grandvuillemin   +4 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Cytologic Findings in Esophageal Perforation: An Institutional Experience With Pleural Fluid Specimens

Diagnostic Cytopathology, EarlyView.
ABSTRACT Introduction Esophageal perforation (EP) is a rare but life‐threatening condition, and most cases are due to iatrogenic causes. The rest occur spontaneously, due to malignancies, or trauma. The mortality rates can approach 50%, and delayed diagnosis of EP exacerbates patient outcomes.
Mason Marshall, Samer Khader, Sigfred Lajara, Liron Pantanowitz   +3 more
wiley   +1 more source

STUDY ON PLEURAL EFFUSION FOR DIAGNOSTIC APPROACH

National Journal of Medical Research, 2020
Background: Pleural effusion occur because of abnormal collection of fluid in pleural cavity. There are various causes of pleural effusion so we have diagnose these cause and treat underlying cause.
Bhavesh M Patel, Jayant B Chauhan
doaj  

Sheath‐assisted microfluidics for elasto‐inertial manipulation of micro/nanoparticles: From theory to biomedical applications

Droplet, EarlyView.
This review examines sheath‐assisted elasto‐inertial microfluidics, where viscoelastic and inertial forces synergize to manipulate particles. It analyzes the underlying mechanisms, system designs, and biomedical applications, proposing future research to advance high‐precision technologies.
Huan Wang, Yanting Wang, Yibo Cui, Limiao Yin, Jinwen Li, Yanxuan Wu, Piwu Li, Lei Zhao, Xiaowen Huang   +8 more
wiley   +1 more source

To Assess Diagnostic value of Lymphocyte // Neutrophil ratio and Adenosine Deaminase in the Diagnosis of Exudative Tubercular Pleural Effusion

MRIMS Journal of Health Sciences, 2019
Background: Adenosine deaminase (ADA) is considered a valuable tool in the diagnosis of extra pulmonary tuberculosis. Objective: To evaluate the role of ADA and L/N ratio in the diagnosis of tuberculous pleural effusion in patients with exudative ...
K Raj Kumar, Raghu Vamsi, Soumya Rani
doaj   +1 more source

Identifying Malignant Pleural Effusion by A Cancer Ratio (Serum LDH: Pleural Fluid ADA Ratio)

Lung, 2015
AimWe studied the diagnostic potential of serum lactate dehydrogenase (LDH) in malignant pleural effusion.MethodsRetrospective analysis of patients hospitalized with exudative pleural effusion in 2013.ResultsSerum LDH and serum LDH: pleural fluid ADA ...
Akash Verma, J. Abisheganaden, Richard W. Light   +2 more
semanticscholar   +1 more source