Klotho controls the brain–immune system interface in the choroid plexus [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Global depletion of klotho accelerates aging, whereas klotho overexpression counteracts aging-related impairments. Why klotho is expressed at much higher levels in the choroid plexus than in other brain regions is unknown.
Lei Zhu +7 more
semanticscholar +3 more sources
Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles [PDF]
EMBO Molecular Medicine, 2016 Here, we identified release of extracellular vesicles (EVs) by the choroid plexus epithelium (CPE) as a new mechanism of blood–brain communication. Systemic inflammation induced an increase in EVs and associated pro‐inflammatory miRNAs, including miR ...
S. Balusu +11 more
semanticscholar +4 more sources
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited
Fluids and Barriers of the CNS, 2022 Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is continuously replenished by net fluid extraction from the vasculature by the secretory action of the choroid plexus epithelium residing in each of the four ...
N. MacAulay, R. Keep, T. Zeuthen
semanticscholar +1 more source
Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder
Neurology, 2022 The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls.
J. Müller +34 more
semanticscholar +1 more source
The choroid plexus and its role in the pathogenesis of neurological infections
Fluids and Barriers of the CNS, 2022 The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system.
Derick Thompson, C. Brissette, J. Watt
semanticscholar +1 more source
Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Neuroinflammation is a hallmark of multiple sclerosis and is linked to neurodegeneration. This study provides pathophysiological insights into the cross-dependency between neuroinflammation and choroid plexus characteristics in both mice and
V. Fleischer +20 more
semanticscholar +1 more source
Choroid plexus and the blood–cerebrospinal fluid barrier in disease
Fluids and Barriers of the CNS, 2020 The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance.
P. Solár +4 more
semanticscholar +1 more source
3D computerized model for measuring strain and displacement of the brachial plexus following placement of reverse shoulder prosthesis [PDF]
, 2008 The aim of the present study was to develop a method for three-dimensional (3D) reconstruction of the brachial plexus to study its morphology and to calculate strain and displacement in relation to changed nerve position.
Audenaert, Emmanuel +5 more
core +1 more source
PLoS Pathogens, 2020 The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients.
B. O'Hara +4 more
semanticscholar +1 more source
FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour [PDF]
, 2008 Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Ferretti, P. +4 more
core +3 more sources