Results 51 to 60 of about 361,703 (401)

Quantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To quantify the number and volume of whole brain perivascular spaces (PVS) using a detection and segmentation algorithm in participants with multiple sclerosis (MS) and patients with disorders mimicking MS known to potentially influence PVS, such as cerebrovascular disease.
Elle M. Levit, Elizabeth A. Horwath, Daniel L. Schwartz, Lisa C. Silbert, Russell T. Shinohara, Andrew J. Solomon   +5 more
wiley   +1 more source

Delayed clearance of cerebrospinal fluid tracer from choroid plexus in idiopathic normal pressure hydrocephalus

Journal of Cerebral Blood Flow and Metabolism, 2019
Impaired clearance of amyloid-β from choroid plexus is one proposed mechanism behind amyloid deposition in Alzheimer's disease. The present study examined whether clearance from choroid plexus of a cerebrospinal fluid tracer, serving as a surrogate ...
P. Eide, L. Valnes, A. Pripp, K. Mardal, G. Ringstad   +4 more
semanticscholar   +1 more source

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Morphology of the murine choroid plexus: Attachment regions and spatial relation to the subarachnoid space

Frontiers in Neuroanatomy, 2022
The choroid plexus has recently been identified as a possible migration route for peripheral immune cells into the central nervous system. For future investigation of this route, profound knowledge of the morphology of the murine choroid plexus is a ...
Theresa Greiner, Katerina Manzhula, Louise Baumann, Hannes Kaddatz, Jens Runge, Jens Runge, Jonas Keiler, Markus Kipp, Sarah Joost   +8 more
doaj   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Becchis M, Caldwell JD, Caldwell JD, Caldwell JD, Caldwell JD, Christian Melle, Englebienne P, Fassler R, Feldman M, Ferdinand von Eggeling, Forunati N, Gao G, Gustav F. Jirikowski, Hammond GL, Hans-Gert Bernstein, Herbert Z, Hoskins EK, Hryb DJ, Jack D. Caldwell, Jirikowski GF, John Lewis, Joseph DR, Khan MS, Krupenko SA, Lewis JG, Melle C, Paoletti AM, Pardridge WM, Remington SG, Reventos J, Rosner W, Selva DM, Susanne Göthe, Vigh Teichmann I, Wang YM, Zsófia Herbert   +35 more
core   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina [PDF]

, 2012
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize ...
Alessia Fraccaroli, Attila Aszodi, Claudio A Franco, Eloi Montanez, Emanuel Rognoni, Filipa Neto, Holger Gerhardt, Holger Gerhardt, Markus Rehberg, Roland Wedlich-Söldner, Ulrich Pohl   +10 more
core   +5 more sources

Precise Quantification of Angiogenesis in 3D Biomaterials Using in Vitro CAM Models: Enhancing 3Rs in Research and Minimizing in Vivo Dependency

Advanced Functional Materials, EarlyView.
The study develops elastin–fibrin scaffolds and evaluates angiogenesis using the chorioallantoic membrane (CAM) model. Advanced imaging with confocal microscopy and Indocyanine Green dye enables precise 3D quantification of vascular networks. Findings demonstrate superior microvessel visualization compared to micro‐CT using Microfil and Optiray 350 ...
Ece Melis Er, Martha Patricia Pérez González, Beatriz Gil Garrido, Jasmine Ho, Hae‐Won Kim, Jonathan Campbell Knowles, Jia Hua, Ferdinand Lali, Prasad Sawadkar   +8 more
wiley   +1 more source

Ethanol Ablation of a Peripheral Nerve Sheath Tumor Presenting as a Small Bowel Obstruction. [PDF]

, 2015
Ethanol has historically been used as an ablative agent for a variety of lesions. One of the more common applications of this technique is celiac plexus neurolysis; however, recent reports have suggested a role for the endoscopic alcohol ablation of a ...
Chang, Kenneth, Chen, Chien-Lin, Chin, Matthew, Lee, John, Samarasena, Jason   +4 more
core   +1 more source