Results 221 to 230 of about 44,745 (266)

Influence of LA and GA Sequence in the PLGA Block on the Properties of Thermogelling PLGA-PEG-PLGA Block Copolymers

Biomacromolecules, 2011
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths but different sequences of D,L ...
Lin, Yu, Zheng, Zhang, Jiandong, Ding
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Effect of PLGA block molecular weight on gelling temperature of PLGA‐PEG‐PLGA thermoresponsive copolymers

Journal of Polymer Science Part A: Polymer Chemistry, 2018
ABSTRACTThermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l‐lactic acid‐co‐glycolic acid)‐b‐poly(ethylene glycol)‐b‐poly(d,l‐lactic acid‐co‐glycolic acid) (PLGA‐PEG‐PLGA) triblock copolymers exhibit a sol–gel transition upon heating.
Noam Y. Steinman, Moran Haim‐Zada, Isaac A. Goldstein, Ayelet H. Goldberg, Tom Haber, Jacob M. Berlin, Abraham J. Domb   +6 more
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Release of rifampicin from chitosan, PLGA and chitosan-coated PLGA microparticles

Colloids and Surfaces B: Biointerfaces, 2008
Recently three groups of rifampicin (RIF)-loaded microparticles (MPs), consisting of chitosan (CHT), PLGA and PLGA/CHT mixtures, were assessed in terms of RIF-loading and retention during nebulisation. The CHT-coated PLGA MPs were found to exhibit high RIF-loading ability together with nebulisation ability, stability, and mucoadhesive properties.
MANCA, MARIA LETIZIA, Loy G, Zaru M, FADDA, ANNA MARIA, Antimisiaris SG   +4 more
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Synthesis and characterization of elastic PLGA/PCL/PLGA tri-block copolymers

Journal of Biomaterials Science, Polymer Edition, 2002
Various ABA-type tri-block copolymers composed of poly(L-lactide) (PLA) or poly (lactide-co-glycolide) (PLGA) as the side A block and poly(epsilon-caprolactone) (PCL) as the middle B block were synthesized to produce rapidly degrading elastic matrices useful for tissue engineering scaffolds.
Choi, SH, Park, TG
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PLGA–PEG–PLGA hydrogel for ocular drug delivery of dexamethasone acetate

Drug Development and Industrial Pharmacy, 2010
This study aims to investigate the suitability of thermosensitive triblock polymer poly-(DL-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA as a matrix material for ocular delivery of dexamethasone acetate (DXA).The copolymer was synthesized and evaluated for its thermosensitive and gelation properties.
Yuan, Gao, Yan, Sun, Fuzheng, Ren, Shen, Gao   +3 more
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PLGA-Mikropartikel

2022
Diese Arbeit handelt von der Charakterisierung der Größe sowie Größenverteilung und freisetzungsspezifischer Eigenschaften von Testosteronbeladenen Mikropartikeln, welche mit PLGA unterschiedlicher Molekulargewichte mittels Solvent Evaporation Methode hergestellt wurden. Weiters wurde die Möglichkeit einer Oberflächenoptimierung von PLGA-Mikropartikel,
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A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel

Journal of Drug Targeting, 2010
The aim of this study was to investigate the suitability of poly-(d,l-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer as a matrix material for a sustained-release system for docetaxel (DTX). The copolymers were synthesized by ring-opening polymerization reaction and characterized by (1)H-NMR and gel permeation ...
Yuan, Gao, Fuzheng, Ren, Baoyue, Ding, Ningyun, Sun, Xiang, Liu, Xueying, Ding, Shen, Gao   +6 more
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Modulating the Thermoresponsive Characteristics of PLGA–PEG-PLGA Hydrogels via Manipulation of PLGA Monomer Sequences

Biomacromolecules
Hydrogels are promising materials for biomedical applications, particularly in drug delivery and tissue engineering. This study highlights thermoresponsive hydrogels, specifically poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA triblock copolymers, and introduces a feed rate-controlled polymerization (FRCP) method. By utilizing an
SeongHoon Jo, Soonjong Roh, Jaemin Shim, Ji Woong Yu, Youngmee Jung, Woo Young Jang, Bumjoon Seo, You-Yeon Won, Jin Yoo   +8 more
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PLGA Microspheres Encapsulating siRNA

2014
The therapeutic use of small interfering RNA (siRNA) represents a new and powerful approach to suppress the expression of pathologically genes. However, biopharmaceutical drawbacks, such as short half-life, poor cellular uptake, and unspecific distribution into the body, hamper the development of siRNA-based therapeutics.
DE ROSA, GIUSEPPE, SALZANO, GIUSEPPINA
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Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Advanced Healthcare Materials, 2017
AbstractPoly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix.
Cláudia Martins, Flávia Sousa, Francisca Araújo, Bruno Sarmento   +3 more
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