Results 231 to 240 of about 44,745 (266)
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Self-healing of pores in PLGAs
Journal of Controlled Release, 2015Self-healing of pores in Poly(lactic-co-glycolic acid)s (PLGA) plays an important role in the encapsulation and controlled release of drugs from PLGA microparticles. Despite the importance of this phenomenon, neither the mechanics of the deformation nor the material properties that control it have been fully studied.
J, Huang +3 more
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Functionalization Conditions of PLGA‐PEG‐PLGA Copolymer with Itaconic Anhydride
Macromolecular Symposia, 2010AbstractSummary: Biodegradable thermosensitive triblock copolymers based on poly(ethylene glycol) and poly(lactic‐co‐glycolic acid) (PLGA‐PEG‐PLGA) prepared via ring opening polymerization were modified by itaconic anhydride (ITA), which gives copolymer both reactive double bonds and functional carboxylic acid groups essential for the reaction with ...
Lenka Michlovská +5 more
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Synthesis and Characterization of PLGA Nanoparticles
Journal of Biomaterials Science, Polymer Edition, 2006Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensively describe the top-down synthesis techniques ...
Carlos E. Astete, Cristina M Sabliov
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Rheological properties of PLGA‐PEG‐PLGA copolymers for ophthalmic injection
Journal of Applied Polymer Science, 2011AbstractPolymer rheological property is one of intrinsic properties for the design and preparation of intravitreal injection systems. Rheological behaviors of thermosensitive poly(lactic acid‐co‐glycolic acid)‐poly(ethylene glycol)‐poly(lactic acid‐co‐glycolic acid) (PLGA‐PEG‐PLGA) triblock copolymers were investigated in this article.
Bochu Wang +3 more
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PLGA Nanoparticles and Transdermal Delivery
Recent Patents on Nanotechnology, 2023openaire +2 more sources
Solubility of Ketoprofen in colloidal PLGA
International Journal of Pharmaceutics, 2010The successful design and development of pharmaceutical drug-polymer composites requires detailed information about the phase behavior of the drug-polymer binary system. This study presents an extended investigation of the phase equilibrium established between the chiral anti-inflammatory drug Ketoprofen (KET) and the bio-compatible and biodegradable ...
Kluge J, Mazzotti M, Muhrer G
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International Journal of Pharmaceutics, 2005
The basic characteristics and the biodistribution properties of nanoparticles prepared from mixtures of poly(lactide-co-glycolide) (PLGA) with poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) copolymers were investigated. A PLGA(45)-PEG(5) copolymer of relatively low PEG content and a PLGA(5)-PEG(5) copolymer of relatively high PEG content ...
A, Beletsi, Z, Panagi, K, Avgoustakis
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The basic characteristics and the biodistribution properties of nanoparticles prepared from mixtures of poly(lactide-co-glycolide) (PLGA) with poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) copolymers were investigated. A PLGA(45)-PEG(5) copolymer of relatively low PEG content and a PLGA(5)-PEG(5) copolymer of relatively high PEG content ...
A, Beletsi, Z, Panagi, K, Avgoustakis
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Biodegradable Triblock Copolymer of PLGA-PEG-PLGA Enhances Gene Transfection Efficiency
Pharmaceutical Research, 2004A tri-block copolymer of PLGA-PEG-PLGA was used as an excipient to enhance the gene transfection efficiency of various cationic polymeric carriers.Luciferase plasmid DNA was complexed with polyethylenimine for gene transfection. Various concentrations of PLGA-PEG-PLGA copolymer up to 0.5% were added in the transfection medium to explore whether the ...
Jeong, JH, Kim, SW, Park, TG
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The thermogelling PLGA–PEG–PLGA block copolymer as a sustained release matrix of doxorubicin
Biomaterials Science, 2013This study is aimed at extending a thermo-induced physical hydrogel as a localized delivery system of the antitumor drug doxorubicin (DOX). An amphiphilic triblock copolymer consisting of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) was synthesized.
Lin, Yu +4 more
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Treating colon cancer with injectable PLGA–PEG–PLGA as a carrier for iodine-125
Biotechnology Letters, 2013Provide a safer way for treating various cancers with PLGA-PEG-PLGA (PPP)-embedded iodine-125. To improve the safety of iodine treatment for colon cancer, iodine-125 solution was embedded into PLGA-PEG-PLGA (PPP) (synthesized by bulk co-polymerization of DL-polylactide glycolide and PEG).
Zhenhuan, Ma +5 more
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