Results 111 to 120 of about 282,554 (281)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

IGUANA Architecture, Framework and Toolkit for Interactive Graphics

open access: yes, 2003
IGUANA is a generic interactive visualisation framework based on a C++ component model. It provides powerful user interface and visualisation primitives in a way that is not tied to any particular physics experiment or detector design.
Alverson, George   +5 more
core   +1 more source

FM/CW radar system [PDF]

open access: yes, 1978
An FM/CW radar system is presented with improved noise discrimination in which the received signal is multiplied by a sample of the transmitted signal, and the product signal is employed to deflect a laser beam as a function of frequency. The position of
Brey, H., Geise, P. E., Jr.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Lower Thoracic Epidural Block in Diaphragmatic Plication: A Case Report

open access: yesAnnals of Cardiac Anaesthesia
Acquired diaphragmatic eventration (DE) is an uncommon condition characterized by all or a portion of the diaphragmatic muscle replaced by a thin fibroelastic sheath, resulting in an abnormal elevation of the hemidiaphragm.
Jes Jose   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Do Absorbable Sutures Work for Rectus Diastasis Repair in Abdominoplasty Patients?

open access: yesAesthetic Surgery Journal Open Forum
BackgroundThe standard treatment for rectus diastasis is rectus sheath plication during abdominoplasty. Lasting correction of diastasis is essential, but there is currently a debate as to whether absorbable or nonabsorbable rectus plication achieves a ...
Brandon T Jackson   +6 more
doaj   +1 more source

In-Vivo Bytecode Instrumentation for Improving Privacy on Android Smartphones in Uncertain Environments [PDF]

open access: yes, 2012
In this paper we claim that an efficient and readily applicable means to improve privacy of Android applications is: 1) to perform runtime monitoring by instrumenting the application bytecode and 2) in-vivo, i.e. directly on the smartphone.
Allix, Kevin   +4 more
core   +4 more sources

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