Results 41 to 50 of about 10,555 (279)

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science, EarlyView.
This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
wiley   +1 more source

Unraveling the Genome of a High Yielding Colombian Sugarcane Hybrid

Frontiers in Plant Science, 2021
Recent developments in High Throughput Sequencing (HTS) technologies and bioinformatics, including improved read lengths and genome assemblers allow the reconstruction of complex genomes with unprecedented quality and contiguity. Sugarcane has one of the
Jhon Henry Trujillo-Montenegro, Jhon Henry Trujillo-Montenegro, María Juliana Rodríguez Cubillos, Cristian Darío Loaiza, Manuel Quintero, Héctor Fabio Espitia-Navarro, Fredy Antonio Salazar Villareal, Carlos Arturo Viveros Valens, Andrés Fernando González Barrios, José De Vega, Jorge Duitama, John J. Riascos   +11 more
doaj   +1 more source

Benchmarking Ploidy Estimation Methods for Bulk and Single‐Cell Whole Genome Sequencing

Advanced Science, EarlyView.
It comprehensively benchmarks computational tools for ploidy estimation from bulk and single‐cell whole‐genome sequencing data. The results highlight the strengths and limitations of each method under different conditions and identify PURPLE and SeCNV show top performance in bulk and single‐cell settings, respectively.
Yawei Song, Zilv Mei, Qijie Zheng, Qingqing Yuan, Yu Liang, Jiaqi Gao, Lang Zhou, Shuheng Wu, Wei Wu   +8 more
wiley   +1 more source

RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B‐Cell Acute Lymphoblastic Leukemia

Advanced Intelligent Systems, EarlyView.
Here, we present RanBALL, an ensemble random projection‐based model for accurate and cost‐effective identification of B‐cell acute lymphoblastic leukemia subtypes is presented. By preserving patient‐to‐patient distance after dimension reduction by random projection and ensemble learning, RanBALL can facilitate the discovery of B‐ALL subtype‐specific ...
Lusheng Li, Hanyu Xiao, Xinchao Wu, Zhenya Tang, Joseph D. Khoury, Jieqiong Wang, Shibiao Wan   +6 more
wiley   +1 more source

Ploidy and fruit trait variation in oil-tea Camellia: Implications for ploidy breeding

Journal of Integrative Agriculture
Plant polyploidy often occurs in conjunction with higher yield and superior quality. Therefore, obtaining polyploid germplasms is a significant part of breeding.
Yanmin Li, Liangjing Yin, Xianyu He, Cenlong Hu, Ronghua Wu, Qian Long, Shixin Xiao, Deyi Yuan   +7 more
doaj   +1 more source

Genomic prediction with machine learning in sugarcane, a complex highly polyploid clonally propagated crop with substantial non‐additive variation for key traits

The Plant Genome, 2023
Sugarcane has a complex, highly polyploid genome with multi‐species ancestry. Additive models for genomic prediction of clonal performance might not capture interactions between genes and alleles from different ploidies and ancestral species.
Chensong Chen, Owen Powell, Eric Dinglasan, Elizabeth M. Ross, Seema Yadav, Xianming Wei, Felicity Atkin, Emily Deomano, Ben J. Hayes   +8 more
doaj   +1 more source

Reconstructing the evolutionary history of herbaceous crops through trait‐based ecology

American Journal of Botany, EarlyView.
Abstract Reconstructing the evolution of crop plants is fundamental to understanding their origins, ecological adaptations, and impacts on ecosystem processes. However, our understanding of crop evolution stems largely from archaeology and genetics, with less focus on a trait‐based ecological approach.
Alicia Gómez‐Fernández
wiley   +1 more source

Transcriptome Profile Analysis on Ovarian Tissues of Autotetraploid Fish and Diploid Red Crucian Carp

Frontiers in Genetics, 2019
Polyploidization can significantly alter the size of animal gametes. Autotetraploid fish (RRRR, 4nRR = 200) (4nRR) possessing four sets of chromosomes were derived from whole-genome duplication in red crucian carp (RR, 2n = 100) (RCC).
Yude Wang, Minghe Zhang, Qinbo Qin, Yajun Peng, Xu Huang, Chongqing Wang, Liu Cao, Wuhui Li, Min Tao, Chun Zhang, Shaojun Liu   +10 more
doaj   +1 more source

Causes of delayed angiosperm diversification: The photosynthetic revolution, increased opportunity costs of anti‐herbivore defenses, selection for qualitative toxins, and acceleration of plant–herbivore coevolution

American Journal of Botany, EarlyView.
Abstract Why did it take so long for angiosperms to diversify after they arose? Here I consider the indirect but potentially crucial impact of the “photosynthetic revolution” on plant–herbivore coevolution. Increased vein density in fossil leaves implies a doubling in photosynthesis 125–100 million years ago.
Thomas J. Givnish
wiley   +1 more source

Identification of sources resistant to a virulent Fusarium wilt strain (VCG 0124) infecting Cavendish bananas

Scientific Reports, 2021
Bananas are vital for food security in many countries, and half of banana production relies solely on ‘Cavendish’ (AAA), which is presently threatened by the fungal pathogen Fusarium oxysporum f. sp. cubense (Foc) tropical race 4.
R. Thangavelu, M. S. Saraswathi, S. Uma, M. Loganathan, S. Backiyarani, P. Durai, E. Edwin Raj, N. Marimuthu, G. Kannan, R. Swennen   +9 more
doaj   +1 more source