Results 61 to 70 of about 12,551 (327)

Chromosome-breakage genomic instability and chromothripsis in breast cancer [PDF]

, 2014
Background: Chromosomal breakage followed by faulty DNA repair leads to gene amplifications and deletions in cancers. However, the mere assessment of the extent of genomic changes, amplifications and deletions may reduce the complexity of genomic data ...
Barrett, Michael T, Basik, Mark, Greenwood, Celia MT, Klein, Kathleen, Lenkiewicz, Elizabeth, Nabavi, Sheida, Przybytkowski, Ewa   +6 more
core   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Genomic prediction with machine learning in sugarcane, a complex highly polyploid clonally propagated crop with substantial non‐additive variation for key traits

The Plant Genome, 2023
Sugarcane has a complex, highly polyploid genome with multi‐species ancestry. Additive models for genomic prediction of clonal performance might not capture interactions between genes and alleles from different ploidies and ancestral species.
Chensong Chen, Owen Powell, Eric Dinglasan, Elizabeth M. Ross, Seema Yadav, Xianming Wei, Felicity Atkin, Emily Deomano, Ben J. Hayes   +8 more
doaj   +1 more source

Unraveling the Genome of a High Yielding Colombian Sugarcane Hybrid

Frontiers in Plant Science, 2021
Recent developments in High Throughput Sequencing (HTS) technologies and bioinformatics, including improved read lengths and genome assemblers allow the reconstruction of complex genomes with unprecedented quality and contiguity. Sugarcane has one of the
Jhon Henry Trujillo-Montenegro, Jhon Henry Trujillo-Montenegro, María Juliana Rodríguez Cubillos, Cristian Darío Loaiza, Manuel Quintero, Héctor Fabio Espitia-Navarro, Fredy Antonio Salazar Villareal, Carlos Arturo Viveros Valens, Andrés Fernando González Barrios, José De Vega, Jorge Duitama, John J. Riascos   +11 more
doaj   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Transcriptome Profile Analysis on Ovarian Tissues of Autotetraploid Fish and Diploid Red Crucian Carp

Frontiers in Genetics, 2019
Polyploidization can significantly alter the size of animal gametes. Autotetraploid fish (RRRR, 4nRR = 200) (4nRR) possessing four sets of chromosomes were derived from whole-genome duplication in red crucian carp (RR, 2n = 100) (RCC).
Yude Wang, Minghe Zhang, Qinbo Qin, Yajun Peng, Xu Huang, Chongqing Wang, Liu Cao, Wuhui Li, Min Tao, Chun Zhang, Shaojun Liu   +10 more
doaj   +1 more source

RanBALL: An Ensemble Machine Learning Framework for Accurate Subtype Identification of Pediatric B‐Cell Acute Lymphoblastic Leukemia

Advanced Intelligent Systems, EarlyView.
Here, we present RanBALL, an ensemble random projection‐based model for accurate and cost‐effective identification of B‐cell acute lymphoblastic leukemia subtypes is presented. By preserving patient‐to‐patient distance after dimension reduction by random projection and ensemble learning, RanBALL can facilitate the discovery of B‐ALL subtype‐specific ...
Lusheng Li, Hanyu Xiao, Xinchao Wu, Zhenya Tang, Joseph D. Khoury, Jieqiong Wang, Shibiao Wan   +6 more
wiley   +1 more source

Identification of sources resistant to a virulent Fusarium wilt strain (VCG 0124) infecting Cavendish bananas

Scientific Reports, 2021
Bananas are vital for food security in many countries, and half of banana production relies solely on ‘Cavendish’ (AAA), which is presently threatened by the fungal pathogen Fusarium oxysporum f. sp. cubense (Foc) tropical race 4.
R. Thangavelu, M. S. Saraswathi, S. Uma, M. Loganathan, S. Backiyarani, P. Durai, E. Edwin Raj, N. Marimuthu, G. Kannan, R. Swennen   +9 more
doaj   +1 more source

P-163 Effects of Early Modes of Cell Division on Blastocyst Ploidy [PDF]

, 2022
Y Mizobe, Y Kuwatsuru, Y Kuroki, Y Fukumoto, M Tokudome, H Moewaki, M Tabira, T Iwakawa, K Takeuchi   +8 more
openalex   +1 more source

Phylogenomics reveals the evolution of floral traits associated with pollinators and pollinator–prey conflict within the carnivorous Pinguicula subgenus Temnoceras

American Journal of Botany, EarlyView.
Abstract Premise The carnivorous plant genus Pinguicula (Lentibulariaceae) exhibits remarkable floral diversity associated with pollination, particularly in the largest subgenus Temnoceras, which spans Mexico and Central America. Despite this diversity, the relationships between species and the evolution of key floral traits remain unresolved. Here, we
Yunjia Liu, Qianshi Lin, Steven J. Fleck, Martín Mata‐Rosas, Enrique Ibarra‐Laclette, Tanya Renner   +5 more
wiley   +1 more source