Results 91 to 100 of about 4,496,478 (332)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A STRUGGLE FOR LOVE OF BELLA SWAN REFLECTED IN NEW MOON MOVIE: AN INDIVIDUAL PSYCHOLOGICAL APPROACH

English Review: Journal of English Education, 2012
This paper described the struggle for love of Bella Swan reflected in New Moon movie by using Alfred Adler’s individual psychology and analyzed the plot of the movie.
Ayu Riska Lestari
doaj  

A graphical plot for use in the microscopical determination of the plagioclase feldspars [PDF]

, 1913
F. E. Wright
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Biographic Context in V. V. Nabokov’s Novels “Glory” and “Transparent Things”

Научный диалог, 2019
Novels by V. Nabokov “Glory” and “Transparent Things” are considered from the point of view of representation of biographical material in them. The references in these novels to the works of Russian and foreign literature, to the biographies of writers ...
E. G. Nikolayeva
doaj   +1 more source

Application of Volcano Plots in Analyses of mRNA Differential Expressions with Microarrays

, 2013
Volcano plot displays unstandardized signal (e.g. log-fold-change) against noise-adjusted/standardized signal (e.g. t-statistic or -log10(p-value) from the t test).
Alvord W. G., Auer P. L., Chen Y., Chen Z., Cohen J., Fechner G. T., Guyon I., Göhlmann H., Lee J., Li C., Schwender H., Smyth G. K., Snedecor G. W., Trevino V., Vandesompele J., Welsh B. L., WENTIAN LI, Zhao C.   +17 more
core   +1 more source

SAMPLING SOIL PLOTS [PDF]

, 1920
Firman E. Bear, G. M. McClure
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

LINGUISTIC FEATURES OF THE MEMOIR GENRE WORK "MEMOIRES ET DICTEES" ("MEMOIRS AND NOTES") BY G. SIMENON

Гуманитарные и юридические исследования, 2021
The article focuses on the problem of identification and analysis of specific features of the idiostyle of Georges Simenon's memoirs "Memoires et dictees ("Memoirs and Notes") from the viewpoint of modern linguistics of the text and complex stylistic ...
N. Dyumon
doaj  

Ballad in Modern Russian Poetry: Ways and Nature of Genre Form Transformation

Научный диалог, 2019
The article analyzes the features of transformation of ballad genre form in modern Russian poetry. Relying on theoretical propositions about the specifics of the genre, developed in the works of Yu. N. Tynianov and M. M. Bakhtin, the nature of changes in
O. Yu. Osmukhina, S. P. Gudkova
doaj   +1 more source