Results 131 to 140 of about 4,756,633 (305)
The effects of a chemosterilant (Mestranol) on population and behavior in the Richardson's ground squirrel (Spermophilus richardsonii) in Alberta [PDF]
, 1974 A chemosterilant, mestranol, was administered to three populations of Richardson's ground squirrel in southeastern Alberta. Mestranol was given to all squirrels in one plot, to only 50 percent in another plot, while a third plot remained as control.
Goulet, Louise A., Sadleir, R. M. F. S.
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Plot-based urbanism : towards time-consciousness in place-making [PDF]
, 2010 Some of us have recently argued that what we still miss is the serious consideration of the factor of time in urbanism, or, in other words, a deeper "time conscious" approach (Thwaites, Porta, Romice, & Greaves, 2008).
Porta, Sergio, Romice, Ombretta
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
TEMA VE YAPI BAĞLAMINDA CORCİ ZEYDAN’IN İSTİBDÂDU’L-MEMÂLİK İSİMLİ ROMANI
Fırat Üniversitesi İlahiyat Fakültesi Dergisi, 2018 Çağdaş Arap edebiyatının ilk dönemlerinin önemli edebiyatçı ve tarihçilerinden olan Corci Zeydan, yazdığı birçok tarihi roman ile Arap milli uyanışına önemli katkılarda bulunmuştur. Sahip olduğu yenilikçi bakış açısını, hem tarih hem de edebiyat alanında
Enes Erdim, İrfan Kaya
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source