Results 51 to 60 of about 4,496,478 (332)

The multifurcating skyline plot [PDF]

Virus Evolution, 2018
AbstractA variety of methods based on coalescent theory have been developed to infer demographic history from gene sequences sampled from natural populations. The ‘skyline plot’ and related approaches are commonly employed as flexible prior distributions for phylogenetic trees in the Bayesian analysis of pathogen gene sequences.
Hoscheit, Patrick, Pybus, Oliver G.
openaire   +10 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

A simplified modal plotting technique for the representation of complex structural models [PDF]

, 1973
A plotting method has been developed that has proven to be useful in rapidly defining the mode shapes of a complex spacecraft. The reduction of the complex model to a simple stick plot is accomplished by augmenting the existing NASTRAN plot package with ...
Hanlein, S. L.
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

1820: A Year of Conspiracies

Caliban: French Journal of English Studies, 2021
Malcolm Chase’s magisterial 1820: Disorder and Stability in the United Kingdom provided a powerful and richly contextualised account of the complex interactions of high and popular politics in a year of crisis.
Gordon Pentland
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

PROPOSITION D'UN CADRE D'ANALYSE DE LA QUALITE DE L'INFORMATION ENVIRONNEMENTALE DIFFUSEE DANS LES RAPPORTS ANNUELS [PDF]

, 2009
International audienceL'objectif de ce papier est de développer une grille d'analyse de la qualité de l'information environnementale diffusée dans les rapports annuels et donc de définir des critères opérationnels de mesure de la qualité. Une information
Plot, Emmanuelle
core   +1 more source

Efficient plot-based floristic assessment of tropical forests [PDF]

, 2003
The tropical flora remains chronically understudied and the lack of floristic understanding hampers ecological research and its application for large-scale conservation planning.
Chuspe Zans, M., Galiano Sanchez, W., Monteagudo, A.L., Nunez Vargas, P., Pena Cruz, A., Phillips, O.L., Rose, S., Timana, M., Vasquez Marti­nez, R., Yli-Halla, M.   +9 more
core   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Drama and satiric prose by Lutfali Hasanov

Studia Humanitatis, 2023
The article studies drama and prose by Lutfali Hasanov who wrote and created works in Sheki literary atmosphere during the 40-70s of the 20th century and led the literary council of “Sabuhi” for a long time. The ideological relevance of the plays such as
Adishirinov Kamil Fikrat
doaj