Results 51 to 60 of about 1,522,201 (266)

MUSICAL IMAGES AND MOTIVES IN THE POETRY OF A. PLATONOV [PDF]

open access: yesПроблемы исторической поэтики, 2015
Th e fi rst literary experiments of  A. Platonov, like among many novelists of the twenties, are connected with poems, which occupy a signifi cant place in his early works. Poems are the texts where was formed a unique style of  the writer.
Anton V. Khramykh
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Antecknat: Berättandet och jakten mot nollpunkten

open access: yesKulturella Perspektiv, 2012
In this article I discuss the importance of plot not only in narratives but as a means of creating coherence and meaning in existence. There is a delicate balance of plot and characterization that is crucial in every narrative.
Anders Öhman
doaj   +1 more source

Yield and carrying capacity of meadows in Albania [PDF]

open access: yesRatarstvo i Povrtarstvo, 2011
This study was carried out during 2003-2005 and included total meadow surface of 32,000 ha from seven regions throughout Albania (summer meadows of Shishtavec, Gramoz, Çajup, Lenie, Progonat, and winter meadows of Heremec-Delvine and Dukaj).
Hajno Luan, Tahiri Fiqiri
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Domestic and Existential in Stories of Vasily Shukshin and Boris Yekimov

open access: yesНаучный диалог
The shared worldview of the so-called “village” writers often obscures the questions regarding their differing evaluations of social reality, interpretations of historical changes, and understandings of humanity’s place in the world. In this context, the
A. V. Frolova
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Survival Plots [PDF]

open access: yesIndian Journal of Medical and Paediatric Oncology, 2020
Sneha Jatan Bothra, Arpan Jain
openaire   +2 more sources

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