Results 51 to 60 of about 1,581,854 (267)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Domestic and Existential in Stories of Vasily Shukshin and Boris Yekimov
Научный диалогThe shared worldview of the so-called “village” writers often obscures the questions regarding their differing evaluations of social reality, interpretations of historical changes, and understandings of humanity’s place in the world. In this context, the
A. V. Frolova
doaj +1 more source
Epidemiology, 2010 Longitudinal data are key to causal inference in epidemiologic studies. As the number of subjects, frequency of measurements, and period of active data collection grow, so does the size of the data set. As the dataset grows, so do the burden and complexity of graphically exploring and summarizing the data without obscuring salient features. The gold
Bruce J, Swihart +5 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ukrainian Fable in the First Half of the XIX century: the Influence of German Traditions of Genre
Journal of Danubian Studies and Research, 2013 The question about the European sources of the Ukrainian fable in the first half of the XIX century remains not enough researched. The given article investigates the problem of the Ukrainian and German theoretical and art connections in the field of ...
Katerina Makhova
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Zo stratégie Antona Pavloviča Čechova, alebo, Marginália ku kompozícii prozaického textu
Opera slavica, 2008 The basis for searching for the point of intersection between the author and the selected genre of his literary text, between the man and the story he invented became Chekhov's prose work Three Years.
Viera Žemberová
doaj
The Mavlyud (Mawlid) Genre in Bashkir Literature of the Early 20th Century
Oriental Studies, 2018 The spiritual literature distributed in the Urals and Volga region as well as in the North Caucasus was quite diverse and consisted of a large number of scientific and literary genres.
F. Sh. Sibagatov
doaj +1 more source