Results 91 to 100 of about 244,053 (326)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Line plotting program using DI-3000/Grafmaker routines [PDF]

open access: yes
A line plotting program has been developed using the DI-3000 graphics libraries and incorporates Grafmaker subroutines. The program allows multiple lines on a frame and multiple frames per run.
Poppen, William A., Jr.   +1 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

On the exact and numerical solutions to a nonlinear model arising in mathematical biology

open access: yesITM Web of Conferences, 2018
This study acquires the exact and numerical approximations of a reaction-convection-diffusion equation arising in mathematical bi- ology namely; Murry equation through its analytical solutions obtained by using a mathematical approach; the modified exp ...
Yokus Asif   +3 more
doaj   +1 more source

PLTTER user's guide [PDF]

open access: yes
The PLTTER graphics system, which is part of CDDMS is discussed. CDDMS is a comprehensive system for data basing and subsequent plotting of data acquired during wind tunnel tests or from computational flow analyses.
Barlow, A., Hermstad, D., Trosin, J.
core   +1 more source

LevelScheme: A level scheme drawing and scientific figure preparation system for Mathematica

open access: yes, 2005
LevelScheme is a scientific figure preparation system for Mathematica. The main emphasis is upon the construction of level schemes, or level energy diagrams, as used in nuclear, atomic, molecular, and hadronic physics. LevelScheme also provides a general
Caprio   +6 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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