Results 91 to 100 of about 924,706 (320)

Manipulation by visual images in ideological concepts or how the G. Potiomkin's image was "cleaned up"

Cхід, 2018
It is noted in the article that the graphic drawing from the end of the 18th century was actively used in forming public opinion through correction of images.
Viktor Filas
doaj   +1 more source

A Modified Salp Swarm Algorithm Based on the Perturbation Weight for Global Optimization Problems

Complexity, 2020
Metaheuristic algorithms are often applied to global function optimization problems. To overcome the poor real-time performance and low precision of the basic salp swarm algorithm, this paper introduces a novel hybrid algorithm inspired by the ...
Yuqi Fan, Junpeng Shao, Guitao Sun, Xuan Shao   +3 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Multivariate analysis by data depth: descriptive statistics, graphics and inference, (with discussion and a rejoinder by Liu and Singh)

, 1999
A data depth can be used to measure the ‘‘depth’’ or ‘‘outlyingness’’ of a given multivariate sample with respect to its underlying distribution. This leads to a natural center-outward ordering of the sample points.
Regina Y. Liu, J. Parelius, Kesar Singh
semanticscholar   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Produtividade do feijoeiro sob diferentes uniformidades de distribuição de água na superfície e na subsuperfície do solo Dry bean yield under different uniformity of water distribution on soil surface and undersurface

Engenharia Agrícola, 2007
Com o objetivo de comparar a uniformidade de lâminas aplicadas, uniformidade de umidades no solo e produtividade da cultura do feijoeiro, conduziu-se um experimento utilizando a cultivar de feijão IAPAR 57.
José A. Frizzone, Roberto Rezende, Antonio C. A. Gonçalves, Celso Helbel Júnior   +3 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

On the exact and numerical solutions to a nonlinear model arising in mathematical biology

ITM Web of Conferences, 2018
This study acquires the exact and numerical approximations of a reaction-convection-diffusion equation arising in mathematical bi- ology namely; Murry equation through its analytical solutions obtained by using a mathematical approach; the modified exp ...
Yokus Asif, Sulaiman Tukur Abdulkadir, Baskonus Haci Mehmet, Atmaca Sibel Pasali   +3 more
doaj   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source