Results 101 to 110 of about 257,775 (300)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Manipulation by visual images in ideological concepts or how the G. Potiomkin's image was "cleaned up"

open access: yesCхід, 2018
It is noted in the article that the graphic drawing from the end of the 18th century was actively used in forming public opinion through correction of images.
Viktor Filas
doaj   +1 more source

A Modified Salp Swarm Algorithm Based on the Perturbation Weight for Global Optimization Problems

open access: yesComplexity, 2020
Metaheuristic algorithms are often applied to global function optimization problems. To overcome the poor real-time performance and low precision of the basic salp swarm algorithm, this paper introduces a novel hybrid algorithm inspired by the ...
Yuqi Fan   +3 more
doaj   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Graphical patterns in quadratic residues [PDF]

open access: yesAust. Math. Soc. gazette 32 (2005), pp. 42-47, 2004
Plots of quadratic residues display some features that are analyzed mathematically.
arxiv  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

The CRC Plotting Package [PDF]

open access: yes, 1984
The CRC Plotting Package is a device independent graphics system. Subroutines for generating graphics exist for programs written in FORTRAN or C.
Azimi, Mani   +2 more
core   +1 more source

Produtividade do feijoeiro sob diferentes uniformidades de distribuição de água na superfície e na subsuperfície do solo Dry bean yield under different uniformity of water distribution on soil surface and undersurface

open access: yesEngenharia Agrícola, 2007
Com o objetivo de comparar a uniformidade de lâminas aplicadas, uniformidade de umidades no solo e produtividade da cultura do feijoeiro, conduziu-se um experimento utilizando a cultivar de feijão IAPAR 57.
José A. Frizzone   +3 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

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