Results 51 to 60 of about 924,706 (320)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
A modified equation for calculating low density lipoprotein cholesterol in Pakistani population
Khyber Medical University Journal, 2023 OBJECTIVE: To derive an equation for accurate estimation of low-density lipoprotein cholesterol (LDL-C) in the Pakistani population. METHODS: A modified equation was derived on the dataset (n = 59,148) from the Pakistani population, comprising ...
Amjad Nawaz +6 more
doaj +1 more source
gtrellis: an R/Bioconductor package for making genome-level Trellis graphics
BMC Bioinformatics, 2016 Trellis graphics are a visualization method that splits data by one or more categorical variables and displays subsets of the data in a grid of panels.
Z. Gu, R. Eils, M. Schlesner
semanticscholar +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
GenomeGraphs: integrated genomic data visualization with R
BMC Bioinformatics, 2009 Background Biological studies involve a growing number of distinct high-throughput experiments to characterize samples of interest. There is a lack of methods to visualize these different genomic datasets in a versatile manner.
Spellman Paul T +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Reactive Programming for Interactive Graphics [PDF]
arXiv.org, 2014 One of the big challenges of developing interactive statistical applications is the management of the data pipeline, which controls transformations from data to plot.
Yihui Xie, H. Hofmann, Xiaoyue Cheng
semanticscholar +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Proposals on Kaplan–Meier plots in medical research and a survey of stakeholder views: KMunicate
BMJ Open, 2019 Objectives To examine reactions to the proposed improvements to standard Kaplan–Meier plots, the standard way to present time-to-event data, and to understand which (if any) facilitated better depiction of (1) the state of patients over time, and (2 ...
Christopher I Jarvis +5 more
doaj +1 more source
Combination plots as graphical tools in the study of enzyme inhibition [PDF]
Biochemical Journal, 1995 Although statistical regression has become the method of choice in the analysis of enzyme kinetics, graphical methods continue to be useful on account of their illustrative capabilities. It is pointed out in this paper that enzyme inhibition data may be presented more efficiently as a single linear plot than the traditional way as a family of lines ...
openaire +3 more sources