Results 81 to 90 of about 244,053 (326)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
eQTL Viewer: visualizing how sequence variation affects genome-wide transcription
BMC Bioinformatics, 2007 Background Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expression profiles are related with sequence polymorphisms across the genome ...
Zeng Zhao-Bang, Aylor David L, Zou Wei
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Meta-analysis: Its role in psychological methodology [PDF]
Psihološka Obzorja, 2008 Meta-analysis refers to the statistical analysis of a large collection of independent observations for the purpose of integrating results. The main objectives of this article are to define meta-analysis as a method of data integration, to draw attention ...
Andrej Kastrin
doaj
A Modified Salp Swarm Algorithm Based on the Perturbation Weight for Global Optimization Problems
Complexity, 2020 Metaheuristic algorithms are often applied to global function optimization problems. To overcome the poor real-time performance and low precision of the basic salp swarm algorithm, this paper introduces a novel hybrid algorithm inspired by the ...
Yuqi Fan +3 more
doaj +1 more source
User's manual for the coupled rotor/airframe vibration analysis graphic package [PDF]
User instructions for a graphics package for coupled rotor/airframe vibration analysis are presented. Responses to plot package messages which the user must make to activate plot package operations and options are described.
Studwell, R. E.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Engenharia Agrícola, 2007 Com o objetivo de comparar a uniformidade de lâminas aplicadas, uniformidade de umidades no solo e produtividade da cultura do feijoeiro, conduziu-se um experimento utilizando a cultivar de feijão IAPAR 57.
José A. Frizzone +3 more
doaj +1 more source
Escaping RGBland: Selecting Colors for Statistical Graphics [PDF]
, 2007 Statistical graphics are often augmented by the use of color coding information contained in some variable. When this involves the shading of areas (and not only points or lines) - e.g., as in bar plots, pie charts, mosaic displays or heatmaps - it is ...
Hornik, Kurt +2 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source