Results 151 to 160 of about 66,577 (304)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Milling Parameters and Quality of Machined Surface of Wire Arc Additive Manufactured AISI 321 Steel. [PDF]

Materials (Basel)
Zhang Q, Kozlov VN, Klimenov VA, Chinakhov DA, Chernukhin RV, Han Z, Qi M.   +6 more
europepmc   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, EarlyView.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

Tribomechanical Behaviour and Elasto-Plastic Contact Response of 3D-Printed Versus Conventional Polymer Inserts in Robotic Gripping Interfaces. [PDF]

Polymers (Basel)
Păduraru GI, Călin A, Stoica M, Prisecaru DA, Seiciu PL.   +4 more
europepmc   +1 more source

An experimental approach to assess the combined effects of multiple stressors on a large vertebrate species

Conservation Biology, EarlyView.
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta, Catriona M. Harris, Lori H. Schwacke, Len Thomas, Jason B. Allen, Aaron A. Barleycorn, Marco Casoli, Jonathan Crossman, Laura Aichinger Dias, Laura Engleby, Erin LaBrecque, Jenny A. Litz, Katherine A. McHugh, Patrick J. O. Miller, Michael J. Moore, Theoni Photopoulou, Brian M. Quigley, Cynthia R. Smith, Brandon L. Southall, Todd R. Speakman, Ryan Takeshita, Christina N. Toms, Randall S. Wells, Eric S. Zolman, Peter L. Tyack   +24 more
wiley   +1 more source

Integrated Moldboard Ploughing and Organic-Inorganic Fertilization Enhances Maize Yield and Soil Fertility in a Semi-Arid Region of North China. [PDF]

Plants (Basel)
Gao M, Zhen Q, Duan Y, Liu C, Zhou J, Li Y, Zhang X, Wang X, Shi X.   +8 more
europepmc   +1 more source

Does nature shape risk preferences? Evidence from Chile, Norway, and Tanzania

Economic Inquiry, Volume 63, Issue 2, Page 568-590, April 2025.
Abstract Does exposure to a more risky environment affect risk preferences? Going beyond single‐case study evidence, we report results from five surveys conducted in three countries and link this with administrative data to study whether a link between exposure and preferences is detectable and widespread. We find no evidence for endogenous preferences
Florian Diekert, Robbert‐Jan Schaap
wiley   +1 more source

Effects of tillage on the root length and depth distribution of stubble cover crops. [PDF]

Sci Rep
Svoboda P, Raimanova I, Moulik M, Lhotska M, Haberle J, Kas M.   +5 more
europepmc   +1 more source

The commercialization of labour markets: Evidence from wage inequality in the Middle Ages

The Economic History Review, EarlyView.
Abstract This paper moves beyond the focus on ‘average’ wage trends in pre‐industrial economies by examining the broad diversity of pay rates and forms of remuneration across occupations and regions in medieval England. We find that whilst some workers enjoyed substantial growth in wage rates after the Black Death, there was a large group who ...
Jordan Claridge, Vincent Delabastita, Spike Gibbs   +2 more
wiley   +1 more source

Analysis of the Material Removal Process in Precision Milling of AZ91D Magnesium Alloy. [PDF]

Micromachines (Basel)
Korpysa J.
europepmc   +1 more source