Results 251 to 260 of about 298,479 (352)

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

open access: yesAngewandte Chemie International Edition, EarlyView.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer   +11 more
wiley   +1 more source

Hierarchical network of thermal plumes and their dynamics in turbulent Rayleigh-Bénard convection. [PDF]

open access: yesProc Natl Acad Sci U S A
Shevkar PP   +5 more
europepmc   +1 more source

Alkalinity enhancement with sodium hydroxide in coastal ocean waters. [PDF]

open access: yesSci Rep
Wynn-Edwards CA   +7 more
europepmc   +1 more source

Harnessing Machine Learning and Deep Learning Approaches for Laser‐Induced Breakdown Spectroscopy Data Analysis: A Comprehensive Review

open access: yesAnalysis &Sensing, EarlyView.
Laser‐induced breakdown spectroscopy (LIBS), an atomic emission technique, is widely applied in fields like geology and biology. This rapid elemental analysis method leverages computational tools to boost precision and speed up data processing. This review explores machine learning and deep learning methods for analyzing LIBS spectral data, tackling ...
Pegah Dehbozorgi   +3 more
wiley   +1 more source

Plume‐Plateau Interaction

open access: yesAGU Advances
Shichun Huang
doaj   +1 more source

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