Results 101 to 110 of about 29,764,931 (332)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Mandarin Singing Voice Synthesis Based on Harmonic Plus Noise Model and Singing Expression Analysis [PDF]

open access: yes, 2015
The purpose of this study is to investigate how humans interpret musical scores expressively, and then design machines that sing like humans. We consider six factors that have a strong influence on the expression of human singing. The factors are related
Gu, Hung-Yan   +2 more
core  

Exploring the Inert Doublet Model through the dijet plus missing transverse energy channel at the LHC

open access: yes, 2016
In this study of the Inert Doublet Model (IDM), we propose that the dijet + missing transverse energy channel at the Large Hadron Collider (LHC) will be an effective way of searching for the scalar particles of the IDM.
Poulose, P.   +2 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Model Independent Extra-dimension signatures with ATLAS [PDF]

open access: yes, 2000
The generic missing transverse energy signals at LHC for theories having large extra dimensions are discussed. Final states of jets plus missing energy and photons plus missing energy are simulated in the ATLAS detector.
Hinchliffe, I., Vacavant, L.
core   +2 more sources

Real decoupling ghost quantization of the CGHS model for two dimensional black holes

open access: yes, 1994
A complete RST quantization of a CGHS model plus Strominger term is carried out. In so doing a conformal invariant theory with $\kappa=\frac{N}{12}$ is found, that is, without ghosts contribution.
A. Bilal   +10 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

The Effects of Class Size on Student Achievement in Higher Education: Applying an Earnings Function [PDF]

open access: yes, 2002
This paper uses an earnings function to model how class size affects the grade students earn. We test the model using an ordinal logit with and without fixed effects on 363,023 undergraduate observations. We find that class size negatively affects grades.
Christy, Sean M.   +2 more
core   +1 more source

The Charm of the Proton and the $\Lambda _c^{+}$ Production

open access: yes, 1997
We propose a two component model for charmed baryon production in $pp$ collisions consisting of the conventional parton fusion mechanism and fragmentation plus quarks recombination in which a $ud$ valence diquark from the proton recombines with a $c$-sea
Anjos, J. dos   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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