Results 121 to 130 of about 29,764,931 (332)

Dynamic simulation of land use and its response to the ecosystem service value in Puding county from 1973 to 2030

Carsologica Sinica
Puding county is located in the west-central part of Guizhou Province, covering a total area of 1,091 km². It experiences a humid subtropical monsoon climate, characterized by an average annual precipitation of 1,378.2 mm and an average annual ...
Yue LI, Xia FENG, Luhua WU
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Improving Non-English-Majored College Students’ Writing Skills: Combining a Know-Want-Learn Plus Model of Meta-Cognitive Writing Strategy Instruction and Internet-Based Language Laboratory Support

, 2016
This paper reviewed a one-term experiment on integrating internet-based language laboratory (IBLL) in teaching writings kills with the know-want-learn (KWL) plus model to second-year non-English-majored college students from Yangtze University.
You-gen Lou, Lian-song Wu, Honglian Liu, Liyou Chen   +3 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Spatio-temporal Evolution Characteristics and Multi-scenario Simulation of Carbon Sink Spatial Patterns in Towns of Southern Jiangsu

Fengjing Yuanlin
ObjectiveCollaboratively promoting carbon reduction, pollution reduction, green expansion, and growth, while maintaining national ecological security, has become a key focus area in national strategic planning in recent years. However, rapid urbanization
Lingyun FAN, Yuxuan TANG, Yongbing TIAN
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multi-scenario Measurement and Response of Ecological Network Resilience in Urban-Wetland Complexes: Case Studies of Haizhu District, Guangzhou

Fengjing Yuanlin
ObjectiveUrbanization has fragmented ecological habitats, threatening urban ecosystem sustainability. Ecological networks are crucial for maintaining resilience, with dynamic interactions between network systems and urban development.
Minzhi LI, Xiaoyu TIAN
doaj   +1 more source

Predicting Aerosol Based Emissions in a Post Combustion CO2 Capture Process Using an Aspen Plus Model

, 2014
Industrial scale implementation of post combustion CO2 capture (PCCC) can be hindered by solvent emissions due to its impact on the environment and the operating costs.
P. Khakharia, J. Mertens, T. Vlugt, E. Goetheer   +3 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Alterations in mitochondrial base editors enhance targeted editing efficiency for mouse model generation

Molecular Therapy: Nucleic Acids
Mitochondrial DNA (mtDNA) base editors are powerful tools for investigating mitochondrial diseases. However, their editing efficiency can vary significantly depending on the target site within the mtDNA.
Seongho Hong, Sol Pin Kim, Sanghun Kim, Soo Kyung Kang, Sungmo Jung, Yeji Oh, Seung Hee Choi, Su Bin Lee, Hou Cha, Jieun Kim, Jiyoung Bae, Jiyoon Park, Kyoungmi Kim, Chang Geun Choi, Soo-Ji Park, Do Hyun Kim, Lark Kyun Kim, Je Kyung Seong, Hyunji Lee   +18 more
doaj   +1 more source