Results 61 to 70 of about 49,031 (291)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Geoscientific Review on CO and CO₂ Ices in the Outer Solar System

Geosciences, 2022
Ground-based telescopes and space exploration have provided outstanding observations of the complexity of icy planetary surfaces. This work presents our review of the varying nature of carbon dioxide (CO2) and carbon monoxide (CO) ices from the cold ...
Caitlin Ahrens, Hypatia Meraviglia, Christopher Bennett   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

PLuTO: MT for online patent translation [PDF]

, 2010
PLuTO – Patent Language Translation Online – is a partially EU-funded commercialization project which specializes in the automatic retrieval and translation of patent documents.
Sheridan, Páraic, Tinsley, John, Way, Andy   +2 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Editorial

Dhaxalreeb
On 21 January 2025, Redsea Cultural Foundation signed a Memorandum of Understanding with Pluto Journals Ltd and African Books Collective. With this edition, in fact, Dhaxalreeb Academic Journal is officially co-published by the Redsea Cultural Foundation
Jama Musse Jama, Jama Musse Jama
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Crater Dimensions on the Dwarf Planets

The Planetary Science Journal
The icy dwarf planets of Pluto, Charon, and Ceres provide important geologic comparisons for each other as they possess similar gravities and experience impacts of similar velocities compared to larger planets and moons.
Veronica J. Bray, Michael F. Zeilnhofer, S. J. Robbins, P. M. Schenk, Kelsi M. Singer, O. L. White, S. A. Stern, S. D. Benecchi, K. A. Durfey, H. A. Weaver, C. B. Olkin, J. R. Spencer, the New Horizons Geology and Geophysics Investigation Team   +12 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source