Results 51 to 60 of about 971,010 (279)
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Background Pickleball has grown rapidly in popularity in recent years, accompanied by an increasing number of reported injuries among players. Our aim is to determine the epidemiology of pickleball-related injuries at a single academic center and ...
Yue Meng +7 more
doaj +1 more source
Kapitał intelektualny jako istotny czynnik konkurencyjności polskich województw w latach 2016-2020
Celem artykułu jest analiza zależności przyczynowo-skutkowych zachodzących pomiędzy komponentami kapitału intelektualnego województw a ich pozycją konkurencyjną. W tym celu zastosowano metodę PLS-PM. Uzyskane wyniki potwierdziły, że kapitał intelektualny
Monika Osińska
doaj
A New Approach in Joint Optimization of Maintenance Planning, Process Quality and Production Scheduling [PDF]
Shop floor performance has great influence on performance of a manufacturing system. Traditionally, shop floor operational policies concerning maintenance scheduling, quality control and production scheduling have been considered and optimized ...
N. Manavizadeh, E. Azizi Javan
doaj +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
For further reduction of particulate emission from a diesel vehicle, it is fundamentally important to understand in-flame soot formation and oxidation processes.
Katsufumi KONDO +3 more
doaj +1 more source
Summary: A colony is meant to be a symbol manipulating system consisting of as simple as possible components which behave in a cooperative way such that the collective competence is strictly larger (even significantly larger) than the component competences.
Vide, C. Martín, PĂun, Gh.
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source

