Results 131 to 140 of about 1,372,579 (202)

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li   +19 more
wiley   +1 more source

Integrated Single‐Cell RNA Sequencing and Untargeted Metabolomics Reveals β‐Elemene's Immune and Metabolic Modulation in Triple‐Negative Breast Cancer

open access: yesMedComm – Oncology, Volume 5, Issue 3, September 2026.
In a 4T1 TNBC model, β‐elemene suppressed tumor growth and pulmonary metastasis. scRNA‐seq showed it remodeled the tumor microenvironment by reducing cancer‐associated fibroblasts, enhancing antigen presentation, and inhibiting pro‐tumorigenic ECM remodeling. Metabolomics revealed prostaglandin downregulation.
Zhiqiang Luo   +8 more
wiley   +1 more source

A MassQL‐Based Framework for Rule‐Guided MS/MS Class‐Level Retrieval and Analog Discovery of Cannabinoids

open access: yesRapid Communications in Mass Spectrometry, Volume 40, Issue 16, 30 August 2026.
ABSTRACT Rationale Cannabinoids comprise a chemically diverse group of meroterpenoids whose extensive isomerism, variable side‐chain length, and frequent oxidative or rearranged derivatives lead to strongly overlapping yet characteristic MS/MS fragmentation patterns. In untargeted LC–MS/MS datasets, this combination of structural diversity and spectral
Julia Maia Galvão de Queiroz   +4 more
wiley   +1 more source

Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 2, Page 548-556, August 2026.
ABSTRACT Purpose 13C MRI with hyperpolarized [1‐13C]pyruvate enables noninvasive imaging of metabolic pathways. Considering the high dose of pyruvate used in hyperpolarized 13C‐pyruvate studies, circulating 13C‐pyruvate and the resulting 13C‐lactate in plasma may influence subsequent pyruvate metabolism, yet the guidance on consecutive injections does ...
Jun Chen   +12 more
wiley   +1 more source

A 3‐Month Follow‐Up Pilot Study on Accelerated Intermittent Theta Burst Stimulation for Bipolar Depression

open access: yesBipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Approximately 25% of patients with bipolar disorder are reported to have treatment‐resistant bipolar depression (TRBD). Accelerated intermittent Theta Burst Stimulation (aiTBS) is an innovative form of repetitive transcranial magnetic stimulation (rTMS), delivering bursts of stimulation at theta wave frequencies, which are believed ...
Daan Neuteboom   +7 more
wiley   +1 more source

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