Results 141 to 150 of about 36,715 (282)

Mitochondrial depolarization stabilizes the vitamin B₁₂ chaperone MMADHC in the cytosol to increase MTR activity. [PDF]

Proc Natl Acad Sci U S A
Rath SP, Li Z, Guha A, Dong F, Banerjee R, Mootha VK.   +5 more
europepmc   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Mutational landscape of classical myeloproliferative neoplasms in the Western Cape Province, South Africa. [PDF]

Afr J Lab Med
Dicks MJ, Nell EM, Swanepoel C, Abdullah I, Chapanduka ZC.   +4 more
europepmc   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 753-761, September 2026.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Immune and cytokine landscape differs between cytopenic and proliferative phenotypes in primary myelofibrosis. [PDF]

Ther Adv Hematol
Lee SH, Wang YH, Chang YS, Wei CH, Yuan CT, Hou HA, Chou WC, Tien HF, Lin CC.   +8 more
europepmc   +1 more source

Dissecting Bone Marrow Fibrosis in Philadelphia‐Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Philadelphia‐negative myeloproliferative neoplasms (MPN), a spectrum of blood malignancies characterized by uncontrolled myeloid proliferation, persist as a key challenge in onco‐hematology due to their intricate molecular background, heterogeneous clinical phenotypes, and variable prognoses.
Mariagiovanna Ballato, Vincenzo Fiorentino, Gabriele Ricciardi, Pietro Tralongo, Emanuela Germanà, Alessandro Allegra, Fabio Stagno, Guido Fadda, Maurizio Martini   +8 more
wiley   +1 more source

Deep learning differentiates myeloproliferative neoplasms and predicts JAK2 and CALR mutations from bone marrow smears. [PDF]

Ann Hematol
Eckardt JN, Reddy CBV, Hauspurg H, Riechert S, Schmittmann T, Srivastava I, Winter S, Sockel K, Badstübner M, Bornhäuser M, Tiemann M, Middeke JM.   +11 more
europepmc   +1 more source

Next‐Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT This multicentre study investigated the utility of next‐generation sequencing (NGS) to detect and generate hepatitis B virus (HBV) genomes in samples of low viral load (from 0.2 to 6207 IU/mL). 23 HBV DNA‐positive plasma samples of genotypes A‐E and one HBV‐negative control sample were assayed blindly via 9 established NGS methods from 6 ...
Michael X. Fu, Maria F. Perdomo, Sheila F. Lumley, Johan Ringlander, Kai Kean, Kaitlin Reid, Richard Mayne, Oscar Enrique Torres Montaguth, Leysa Forrest, Sarah Buddle, Johannes C. Botha, Joakim B. Stenbäck, Zachery Dickson, Chris Kent, Haiting Chai, Matthew Byott, Leo Hannolainen, Shannah Secret, George Airey, Klaus Hedman, Monique I. Andersson, M. Azim Ansari, Eleni Nastouli, Judith Breuer, Philippa C. Matthews, Tanya Golubchik, William L. Irving, Peter Simmonds, Heli Harvala   +28 more
wiley   +1 more source

Magnetic particle clusters with tunable thrombus penetration for enhanced thrombolysis. [PDF]

Front Bioeng Biotechnol
Lei Y, Liu Z, Fu Z, Xiang S, Peng W, Yao C, He D, Dong S.   +7 more
europepmc   +1 more source