Results 1 to 10 of about 133,257 (324)

Fluorogenic PNA probes [PDF]

Beilstein Journal of Organic Chemistry, 2018
Fluorogenic oligonucleotide probes that can produce a change in fluorescence signal upon binding to specific biomolecular targets, including nucleic acids as well as non-nucleic acid targets, such as proteins and small molecules, have applications in ...
Tirayut Vilaivan
doaj   +4 more sources

Evaluating the effect of ionic strength on duplex stability for PNA having negatively or positively charged side chains. [PDF]

PLoS ONE, 2013
The enhanced thermodynamic stability of PNA:DNA and PNA:RNA duplexes compared with DNA:DNA and DNA:RNA duplexes has been attributed in part to the lack of electrostatic repulsion between the uncharged PNA backbone and negatively charged DNA or RNA ...
N Tilani S De Costa, Jennifer M Heemstra
doaj   +2 more sources

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Frontiers in Microbiology, 2019
Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding ...
Lise Goltermann, Niloofar Yavari, Meiqin Zhang, Anubrata Ghosal, Peter E. Nielsen   +4 more
doaj   +2 more sources

A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA

Molecular Therapy: Nucleic Acids, 2016
Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all of which are severe threats to human health.
Zhengyang Zeng, Shisong Han, Wei Hong, Yange Lang, Fangfang Li, Yongxiang Liu, Zeyong Li, Yingliang Wu, Wenxin Li, Xianzheng Zhang, Zhijian Cao   +10 more
doaj   +2 more sources

Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli

bioRxiv, 2022
Antisense peptide nucleic acids (PNAs) that target mRNAs of essential bacterial genes exhibit specific bactericidal effects in several microbial species, but our mechanistic understanding of PNA activity and their target gene spectrum is limited.
Linda Popella, Jakob Jung, P. Do, Regan J. Hayward, Lars Barquist, J. Vogel   +5 more
semanticscholar   +1 more source

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications

RSC Chemical Biology, 2022
Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine.
C. Suparpprom, T. Vilaivan
semanticscholar   +1 more source

LETRAMENTO EM POLÍTICAS CURRICULARES DE ALFABETIZAÇÃO

Revista Brasileira de Alfabetização, 2023
Este artigo objetiva analisar como duas políticas curriculares recentes - Base Nacional Comum Curricular e a Política Nacional de Alfabetização - se relacionam com o conceito de “letramento”, como proposto por Magda Soares.
Maria Carolina da Silva Caldeira, Rita de Cássia Prazeres Frangella   +1 more
doaj   +1 more source

CONCEPÇÃO DE LEITURA DA POLÍTICA NACIONAL DE ALFABETIZAÇÃO

Revista Brasileira de Alfabetização, 2023
Este artigo objetiva analisar como a Política Nacional de Alfabetização – PNA (2019) propõe o trabalho com a leitura na Educação Infantil. Utiliza, como metodologia, a pesquisa documental, ao analisar o caderno da PNA.
Margarete Sacht Goes, Dania Monteiro Vieira Costa   +1 more
doaj   +1 more source

Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA.

ACS Chemical Biology, 2021
PNA oligomers conjugated to bacteria penetrating peptides (BPPs), such as (KFF)3K, targeting essential bacterial genes, such as acpP, can inhibit bacterial growth at one-digit micromolar concentrations.
Niloofar Yavari, Lise Goltermann, P. Nielsen   +2 more
semanticscholar   +1 more source

Recent developments in mitochondrial medicine (Part 1)

4 open, 2021
Research into elucidating structure and function of mitochondria has been quite steady between the time of discovery during the end of the 19th century until towards the late 1980’s.
Weissig Volkmar, Edeas Marvin
doaj   +1 more source