Results 11 to 20 of about 51,393 (251)

Model-Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing. [PDF]

Clin Pharmacol Ther
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Li J, Metz DK, Green E, Toldi G, Galinsky R, Clark M, Atkinson R, Rudloff I, Owen JC, DiSimone SK, Forster SC, Cho SX, Majid A, Polglase GR, Favilla M, Pharande P, Malhotra A, Roberts CT, Stansfield SH, Sehgal A, Tan K, Gunn AJ, Berger PJ, Veldman A, Hunt RW, Nold-Petry CA, Nold MF, Kirkpatrick CMJ.   +27 more
europepmc   +2 more sources

Programas de Formação de Professores Alfabetizadores: do PROFA à Política Nacional de Alfabetização – PNA

Revista Educação e Políticas em Debate, 2021
O objetivo deste estudo é discutir a respeito das concepções teóricas e dos discursos sobre alfabetização presentes nas políticas públicas ofertadas pelo Ministério da Educação nos últimos vinte anos para formação de professores alfabetizadores: PROFA ...
Liziana Arâmbula Teixeira, Thaise da Silva   +1 more
doaj   +1 more source

Poly(1-Naphthylamine)–Graphene Oxide Nanocomposite Modified Carbon Paste Electrode for the Economical Enzymeless Electrochemical Sensing of Dopamine [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
Dopamine (DA) is a vital neurotransmitter having key roles in regulating various biological functions in animals and the sensitive and selective monitoring of DA in biological fluid is of high significance.
Femina Kanjirathamthadathil Saidu, George Thomas, Alex Joseph, Eldhose Varghese Vadakkechalil   +3 more
doaj   +1 more source

The approach to managing perinatal anxiety: A mini-review

Frontiers in Psychiatry, 2022
Perinatal Anxiety (PNA) is defined as anxiety occurring during pregnancy and up to 12 months post-partum and is estimated to affect up to 20% of women. Risk factors for PNA are multiple and can be classed as psychological, social and biological.
Victoria Anne Silverwood, Laurna Bullock, Katrina Turner, Carolyn A. Chew-Graham, Carolyn A. Chew-Graham, Carolyn A. Chew-Graham, Tom Kingstone, Tom Kingstone   +7 more
doaj   +1 more source

Reconfigurable Smart Contracts for Renewable Energy Exchange with Re-Use of Verification Rules

Applied Sciences, 2022
Smart contracts constitute the foundation for blockchain distributed applications. These constructs enable transactions in trustless environments using consensus algorithms and software-controlled verification rules.
Tomasz Górski
doaj   +1 more source

Simple representation of physiological regulations in a model of lactating female: application to the dairy goat

Animal, 2008
A dynamic model of the lactating dairy goat, combining a minimum of mechanistic representations of homeorhetic regulations and a long-term approach, was developed.
L. Puillet, O. Martin, M. Tichit, D. Sauvant   +3 more
doaj   +1 more source

Is there a relationship between the quality of surface watercourses associated with rural landscapes and the level and type of anthropization in the zone of influence?

Ecología Austral, 2023
The study of the environmental quality of the largest rivers such as the Paraná, is a challenge for the different disciplines of environmental sciences.
M. Leticia Peluso, Pablo M. Demetrio, Constanza Bernasconi, Natalia Aprigliano, Gabriela Riviello López, Mariana Abelando, Federico Rimoldi   +6 more
doaj   +1 more source

Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

Molecules, 2020
Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos, Stanley Oyaghire, Elias Quijano, Adele S. Ricciardi, W. Mark Saltzman, Peter M. Glazer   +5 more
doaj   +1 more source

Acid-base and lipophilic properties of peptide nucleic acid derivatives

Journal of Pharmaceutical Analysis, 2021
The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described.
Pramod Thakare, Francesca Vasile, Maura Vallaro, Sonja Visentin, Giulia Caron, Emanuela Licandro, Silvia Cauteruccio   +6 more
doaj   +1 more source

Identifying remote sources of interannual variability for summer precipitation over Nordic European countries tied to global teleconnection wave patterns

Tellus: Series A, Dynamic Meteorology and Oceanography, 2020
We show evidence that tropical atmospheric variability over the central tropical Pacific modulates the circulation over the western Arctic and the North Atlantic-European sector, impacting the summer precipitation especially over Nordic European ...
Ramón Fuentes-Franco, Torben Koenigk
doaj   +1 more source