Results 31 to 40 of about 35,299 (221)

Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil

open access: yesBrazilian Journal of Infectious Diseases, 2016
Invasive pneumococcal disease is a relevant public health problem in Brazil, especially among children and the elderly. In July/2010 a 10-valent pneumococcal conjugate vaccine was introduced to the immunization schedule of Brazilian children under two ...
Carolina Regis Leite   +5 more
doaj   +1 more source

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults

open access: yesHuman Vaccines & Immunotherapeutics, 2012
HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/− a TLR9 agonist (CPG 7909).
Rasmus Offersen   +5 more
doaj   +1 more source

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft   +18 more
wiley   +1 more source

Anti‐Inflammatory Effects of Flavonoids in Otitis Media: A Systematic Review of Pre‐Clinical Evidence

open access: yesFood Frontiers, EarlyView.
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz   +3 more
wiley   +1 more source

Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2022
Diseases caused by Streptococcus pneumoniae, as well as antibiotic resistance of its serotypes, are the leading cause of death amongst children worldwide.
V. P. Trukhin   +5 more
doaj   +1 more source

Production and efficacy of a low-cost recombinant pneumococcal protein polysaccharide conjugate vaccine. [PDF]

open access: yes, 2018
Streptococcus pneumoniae is the leading cause of bacterial pneumonia. Although this is a vaccine preventable disease, S. pneumoniae still causes over 1 million deaths per year, mainly in children under the age of five.
Abouelhadid, Sherif   +7 more
core   +3 more sources

‘I Think From the Beginning, the Ambitions Were Compromised’: A Case Study of COVAX as Vaccine Equity Policy Operationalisation

open access: yesThe International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background COVAX was designed to support the discovery, development, and distribution of COVID‐19 vaccines globally, at scale and pace. This article examines how COVAX promoted vaccine equity and what lessons can be learnt. Methods Informed by a scoping review of lessons learnt from GHPs, we reviewed 109 documents related to COVAX and other ...
Charnele Nunes   +3 more
wiley   +1 more source

Herd immunity alters the conditions for performing dose schedule comparisons: an individual-based model of pneumococcal carriage

open access: yesBMC Infectious Diseases, 2019
Background There is great interest in the use of reduced dosing schedules for pneumococcal conjugate vaccines, a strategy premised on maintaining an acceptable level of protection against disease and carriage of the organism.
Alan Yang, Francisco Cai, Marc Lipsitch
doaj   +1 more source

Epidemiological approaches to evaluate clinical unmasking of HPV‐associated cervical lesions in the HPV vaccination era

open access: yesInternational Journal of Cancer, EarlyView.
Abstract HPV vaccination reduces the risk of developing HPV‐attributable cancers, including cervical cancer. However, an attenuation of HPV vaccine impact after the implementation of HPV vaccination may occur through clinical unmasking. Clinical unmasking is a distinct and complex phenomenon that arises in the absence of clinical interventions ...
Joseph E. Tota   +8 more
wiley   +1 more source

Reply letter to “response to article by Johnna Perdrizet et al.” by Gomez and colleagues

open access: yesHuman Vaccines & Immunotherapeutics, 2022
This communication seeks to address the questions and criticisms issued by Gomez and colleagues in their letter on our original study “Cost-effectiveness analysis of replacing the 10-valent pneumococcal conjugate vaccine (PCV10) with the 13-valent ...
Johnna Perdrizet   +6 more
doaj   +1 more source

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