Results 91 to 100 of about 108,435 (267)

Adults aged 65 years and older in South Africa have a responsibility to vaccinate against influenza

open access: yesDeveloping World Bioethics, EarlyView.
Abstract In this article, we draw on the thinking about incompleteness and conviviality grounded in Afro‐communitarianism ethics from the Global South to argue that adults aged 65 years and above have a prima facie responsibility to vaccinate against influenza.
Ruach Sarangarajan, Cornelius Ewuoso
wiley   +1 more source

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions

open access: yesThe FEBS Journal, Volume 292, Issue 6, Page 1480-1499, March 2025.
Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub‐optimal in vulnerable populations. Here, we review the latest preclinical and clinical evidence demonstrating that the gut microbiota plays a significant role in regulating immune responses to ...
Charné Rossouw   +2 more
wiley   +1 more source

Time series analysis of Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis [PDF]

open access: yesarXiv, 2013
The aim of this paper is to study the (clinical) time-series data of three diseases with complex dynamics: Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. For this purpose, first all of the time series data are embedded in a vector space of suitable dimension and then the correlation dimension of the above mentioned ...
arxiv  

Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]

open access: yes, 2014
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs and symptoms of human Mendelian diseases in databases such as OMIM and Orphanet.
arxiv   +1 more source

From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection

open access: yesThe FEBS Journal, Volume 292, Issue 8, Page 1868-1883, April 2025.
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly responsive to systemic infection, and upregulate cytokines and antimicrobial compounds in response.
Matthew C. Sinton, Shingo Kajimura
wiley   +1 more source

Novel predictors of infection‐related rehospitalization in older patients with heart failure in Japan

open access: yesGeriatrics &Gerontology International, Volume 25, Issue 4, Page 543-552, April 2025.
The Japanese Cardiovascular Health Study score and estimated glomerular filtration rate were identified as key predictors of infection‐related rehospitalization in older patients with heart failure. Decision tree analysis enabled stratification into low, intermediate and high‐risk groups, offering valuable insights for targeted management and ...
Kei Kawada   +16 more
wiley   +1 more source

Increasing the Discovery Power and Confidence Levels of Disease Association Studies: A Survey [PDF]

open access: yesarXiv, 2017
The majority of common diseases are influenced by multiple genetic and environmental factors such as Cancer. Even though uncovering the main causes of disease is deemed difficult due to the complexity of gene-gene and gene-environment interactions, major research efforts aim at identifying disease risk factors, especially genetic ones.
arxiv  

Shingles & Pneumococcal Vaccines: Recommendations for Older Adults [PDF]

open access: yes, 2018
As the immune system tends to weaken over time, patients aged 50+ begin having increased risk for certain potentially preventable diseases, especially shingles and pneumonia.
Flinn, Benjamin
core   +1 more source

The development of nations conditions the disease space [PDF]

open access: yesarXiv, 2019
Using the economic complexity methodology on data for disease prevalence in 195 countries during the period of 1990-2016, we propose two new metrics for quantifying the relatedness between diseases, or the `disease space' of countries. With these metrics, we analyze the geography of diseases and empirically investigate the effect of economic ...
arxiv  

Rare but not forgotten: A case of meningitis due to ceftriaxone-resistant Streptococcus pneumoniae

open access: yesIDCases, 2018
Despite the dramatic decrease in invasive pneumococcal disease since the widespread use of the first pneumococcal vaccine, invasive and resistant disease still occurs.
Naomi Hauser   +3 more
doaj   +1 more source

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