Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis [PDF]
JCI InsightDespite effective antibiotic therapy, brain-destructive inflammation often cannot be avoided in pneumococcal meningitis. The causative signals are mediated predominantly through TLR-recruited myeloid differentiation primary response adaptor 88 (MyD88 ...
Susanne Dyckhoff-Shen +11 more
doaj +2 more sources
Optimal age targeting for pneumococcal vaccination in older adults; a modelling study
Nature Communications, 2023 Vaccination against invasive pneumococcal disease is recommended for older adults but the optimal age group to target has not been determined and may vary by epidemiological setting.
Deus Thindwa +19 more
doaj +1 more source
Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine. [PDF]
PLoS ONE, 2018 BACKGROUND:Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016-2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 ...
Catherine H Bozio +11 more
doaj +1 more source
Penicillin Resistant Pneumococcal Meningitis in Paediatric Trauma Patient [PDF]
Journal of Clinical and Diagnostic Research, 2018 Pneumococcal meningitis is a life-threatening infection, requiring prompt diagnosis and effective treatment. The approach to therapy in patients with pneumococcal meningitis has changed considerably over the past 20 years because of emerging penicillin ...
Vijeta Bajpai +3 more
doaj +1 more source
Acta Neuropathologica Communications, 2021 Background Patients with pneumococcal meningitis are at risk for death and neurological sequelae including cognitive impairment. Functional genetic polymorphisms of macrophage migration inhibitory factor (MIF) alleles have shown to predict mortality of ...
Anne T. Kloek +6 more
doaj +1 more source
Advances in the pathogenesis and treatment of pneumococcal meningitis [PDF]
VirulenceJianhua Liu, Yiyun Xu
exaly +2 more sources
The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
Acta Neuropathologica Communications, 2022 Pneumococcal meningitis is associated with dysregulation of the coagulation cascade. Previously, we detected upregulation of cerebral plasminogen activator inhibitor-2 (PAI-2) mRNA expression during pneumococcal meningitis.
Nina C. Teske +8 more
doaj +1 more source
Meningococcal and pneumococcal meningitis in Northern Ghana [PDF]
, 2008 Despite improvements in technology, treatments and understanding of how bacterial meningitis develops, the disease remains a potentially life-threatening emergency capable of causing significant morbidity and mortality. N. meningitidis, S.
Forgor, Abdulai Adams
core +1 more source
Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. [PDF]
, 2009 During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages.
Häcker Georg +20 more
core +2 more sources
Pneumococcal Meningitis in Adults after Introduction of PCV7 and PCV13, Israel, July 2009–June 2015
Emerging Infectious Diseases, 2018 The indirect effect of pneumococcal conjugate vaccine on adult pneumococcal meningitis has not been thoroughly investigated. We present data from active surveillance on pneumococcal meningitis in adults in Israel occurring during July 2009–June 2015 ...
Gili Regev-Yochay +10 more
doaj +1 more source