Results 81 to 90 of about 91,384 (208)

Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.

PLoS Pathogens, 2013
Streptococcus pneumoniae (pneumococcal) meningitis is a common bacterial infection of the brain. The cholesterol-dependent cytolysin pneumolysin represents a key factor, determining the neuropathogenic potential of the pneumococci.
Carolin Wippel, Jana Maurer, Christina Förtsch, Sabrina Hupp, Alexandra Bohl, Jiangtao Ma, Timothy J Mitchell, Stephanie Bunkowski, Wolfgang Brück, Roland Nau, Asparouh I Iliev   +10 more
doaj   +1 more source

Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease. [PDF]

, 2010
BACKGROUND: The 7-valent pneumococcal conjugate vaccine has been introduced in national immunisation programmes of most industrialised countries and recently in two African GAVI eligible countries (Rwanda and The Gambia). However the long term effects of
George, Robert, Robert George, Y.H. Choi, Miller, Elizabeth, Edmunds, John W., Elizabeth Miller, Melegaro, Alessia, Yoon Hong Choi, E. Miller, Choi, Yoon Hong, Gay, Nigel J, Edmunds, W John, Nigel J Gay, R. George, W John Edmunds, Alessia Melegaro, N.J. Gay, W.J. Edmunds, Gay, Nigel J., George Robert, Miller Elizabeth, Edmunds W John, Choi Yoon, Gay Nigel J, Melegaro Alessia   +24 more
core   +2 more sources

Development of a Clinical Severity Score for Indian Sickle Cell Anaemia Patients

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Background Sickle cell anaemia (SCA) is a monogenic disorder but shows variable disease severity. We evaluated the utility of paediatric severity scores (PSS) in Indian patients and developed two modified scores: Indian Severity Score 1 (ISS1) by adding four clinical parameters to PSS, and ISS2 by excluding four biochemical measures from ISS1.
Suraj S. Nongmaithem, Amitabh Biswas, Swaroop Iyer, Jandhayala Vyshnavi, Archana Wath, Giriraj R. Chandak, Dipty Jain   +6 more
wiley   +1 more source

Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru

Revista Peruana de Medicina Experimental y Salud Pública, 2016
Objectives. To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru. Materials and Methods.
Long Davalos, Yessica Terrazas, Ana Quintana, Martha Egoavil, Katherine Sedano, María E. Castillo, Isabel Reyes, Eduardo Chaparro, Wilda Silva, Francisco Campos, Andrés Saenz, Roger Hernandez, Olguita del Águila, Daniel Guillén Pinto, Theresa J. Ochoa   +14 more
doaj   +1 more source

A novel case of autosomal recessive CARD11 loss‐of‐function underlying impaired antiviral immunity and a review of literature

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
We report on a patient homozygous for a novel autosomal recessive loss‐of‐function CARD11 variant, with susceptibility to live attenuated virus (LAV) vaccines and impaired clearance of multiple naturally acquired respiratory viral infections. Inborn errors of immunity affecting the CARD11‐BCL10‐MALT1 (CBM) complex should be considered in individuals ...
Hamish Anderson, Cecilia Verryt, Paula Keating, Thomas Saunders, Samuel Dalton, Barry D Hock, Liping Goddard, Kylie Drake, Anja Werno, John O'Donnell, Jeffrey R Stinson, Andrew L Snow, Kuang‐Chih Hsiao   +12 more
wiley   +1 more source

Brain levels of neuropeptide Y in experimental pneumococcal meningitis [PDF]

, 1993
Neuropeptide Y (NPY), which is found in high concentrations in several regions of the brain including nuclei of the brain stem and in nerve fibers surrounding cerebral vessels, has been proposed to play a role in regulating cerebral blood flow (CBF) and ...
Täuber, MG, Kennedy, SL, Guerra-Romero, L, Ferriero, D, Sheldon, RA   +4 more
core   +2 more sources

Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Journal of Neuroinflammation, 2019
Background The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is
E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek   +11 more
doaj   +1 more source

National, regional, and state-level burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in India: modelled estimates for 2000–15

The Lancet Global Health, 2019
Summary: Background: India accounts for a disproportionate burden of global childhood illnesses. To inform policies and measure progress towards achieving child health targets, we estimated the annual national and state-specific childhood mortality and ...
Brian Wahl, PhD, Apoorva Sharan, ScM, Maria Deloria Knoll, PhD, Rajesh Kumar, ProfMD, Li Liu, PhD, Yue Chu, MSPH, David A McAllister, MD, Harish Nair, ProfPhD, Harry Campbell, ProfMD, Igor Rudan, ProfMD, Usha Ram, ProfPhD, Molly Sauer, MPH, Anita Shet, MD, Robert Black, ProfMD, Mathuram Santosham, ProfMD, Katherine L O'Brien, ProfMD, Narendra K Arora, ProfMD   +16 more
doaj   +1 more source

Trends in Meningitis Burden and Projections to 2040: A Secondary Analysis of the Global Burden of Disease Study 2023

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Meningitis remains a global health challenge, characterized by substantial regional and etiologic disparities. This study aimed to analyze recent trends, forecast future burden, and examine the influence of development status on meningitis outcomes.
Mehdi Azizmohammad Looha, Ali Saberi Shahrbabaki, Fatemeh Masaebi, Mahmoud Zamani, Farid Zayeri   +4 more
wiley   +1 more source

Pneumococcal meningitis in children and adults before and after implementation of PCV13 into national pediatric immunization program: A cohort study in Taiwan

Journal of Infection and Public Health
Background: Streptococcus pneumoniae remains a leading cause of bacterial meningitis worldwide. Although pneumococcal conjugate vaccines (PCVs) have markedly reduced vaccine serotypes (VTs) invasive pneumococcal disease, the emergence of non-vaccine ...
Ching-Min Tang, Hsin-Chieh Li, Lin-Hui Su, Jainn-Jim Lin, Shao-Hsuan Hsia, Oi-Wa Chan, En-Pei Lee, Kuang-Lin Lin, Cheng-Hsun Chiu   +8 more
doaj   +1 more source