Results 81 to 90 of about 20,003 (217)
How Far Can we Go? Managing Moyamoya Syndrome in a 3‐Year‐Old With Thalassemia Major: A Rare Pediatric Case From Nepal
Clinical Case Reports, Volume 14, Issue 3, March 2026.ABSTRACT
Moyamoya syndrome (MMS) is a rare progressive cerebrovascular disorder causing stenosis of intracranial arteries and collateral vessel formation. Pediatric presentations often include ischemic strokes, and coexisting Thalassemia Major may worsen vascular outcomes.Kshitiz Parajuli, Abhisek Jha, Aron Neupane, Shristi Gupta, Nischal Timsina, Sagar Bhagat, Raja Babu Gupta, Anand Sah, Anup Katwal +8 morewiley +1 more sourcePneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats [PDF]
, 2007 Bacterial meningitis is associated with high rates of morbidity and mortality, despite advances in antibiotic therapy. Meningitis caused by Streptococcus pneumoniae is associated with a particularly high incidence of neurological sequelae including ...Grandgirard, D, Tauber, Martin G., Pleasure, S J, Leib, Stephen L., Kummer, J, Bifrare, Y-D +5 morecore +1 more sourceBacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.
PLoS Pathogens, 2013 Streptococcus pneumoniae (pneumococcal) meningitis is a common bacterial infection of the brain. The cholesterol-dependent cytolysin pneumolysin represents a key factor, determining the neuropathogenic potential of the pneumococci.Carolin Wippel, Jana Maurer, Christina Förtsch, Sabrina Hupp, Alexandra Bohl, Jiangtao Ma, Timothy J Mitchell, Stephanie Bunkowski, Wolfgang Brück, Roland Nau, Asparouh I Iliev +10 moredoaj +1 more sourceThe Current Landscape and Future Prospects of Vaccine Manufacturing in Africa: Challenges, Innovations, and Opportunities: A Narrative Review
Health Science Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background and Aims
Africa has significant challenges in meeting its vaccination needs, including inadequate manufacturing capacity, infrastructure deficiencies, a scarcity of experienced personnel, regulatory hurdles, restricted access to technology and intellectual property.Courage Chandipwisa, Agness Shimilimo, Olivier Uwishema, Helen Onyeaka +3 morewiley +1 more sourceExtracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]
, 2011 Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.Elke Maier, Fortsch, C., Mitchell, T.J., Benz, Roland, Ma, Jiangtao, Christina Förtsch, Sabrina Hupp, Jiangtao Ma, Timothy J. Mitchell, Iliev, A. I., Maier, Elke, Förtsch, Christina, Maier, E., Hupp, Sabrina, Asparouh I. Iliev, Hupp, S., Mitchell, Timothy J, Roland Benz, Wippel, C., Benz, R., Ma, J., Wippel, Carolin, Iliev, Asparouh I, Carolin Wippel +23 morecore +1 more sourceSplenectomy in β‐thalassemia patients: Practices and risks in a nationwide study
HemaSphere, Volume 10, Issue 5, May 2026.Audrey Benoit, Justine Pages, Sarah Szepetowski, Imane Agouti, Isabelle Thuret, Enora Le Roux, Catherine Badens, Valentine Brousse, NaThalY Network, Catherine Mathey, Louisa Bey, Marie‐Josée Lucchini, Valérie Li Thio Te, Reda Garidi, Loïc Garcon, Corentin Orvain, Jean‐François Brasme, Claire Reynes, Marie Belloy, Julie Durin, Oula Alhindy, Lara Sabbagh, Borhane Slama, Anthony Sanchez, Alice Moulin, Danielle Belgodere, Lise Benjemia, Pauline Simon, Eric Oziol, Nathalie Aladjidi, Yoann Huguenin, Charlotte Jubert, Edouard Forcade, Pierre Duffau, Abdallah Maakaroun, Florence Lachenal, Charline Pegon, Marie‐Helene Odievre, Charlotte Petitdidier, Sai Atmani, Florence Raqbi, Corinne Pondarre, Jenny Youn, Annie Kamdem, Dora Bachir, Pablo Bartolucci, Gonzalo De Luna, Anoosha Habibi, Elena Fois, Antoine Leblanc, Pierre‐Yves Dides, Caroline Makowski, Corinne Armari, Narcisse Elenga, Christelle Chantalat‐Auger, Françoise Driss, Ferielle Zenchri, Corinne Guitton, Mathilde Jehanne, Cecile Stoven, Axel Chaminade, Stephanie Gourdon, Yves Reguerre, Edouard Randriamalala, Véronique Paumier‐Bonjour, Anne Besancon‐Bergelin, Anne Lambilliotte, Benedicte Bruno, Fanny Gonzales, Melissa Barbati, Benjamin Carpentier, Christophe Piguet, Mohamed Touati, Arnaud Hot, Fiorenza Barraco, Giovanna Cannas, Emilie Virot, Romain Fort, Grégoire Ducoux, Hélène Desmurs Clavel, Kamila Kebaili, Nathalie Garnier, Cécile Renard, Yves Bertrand, Anne‐Laure Peugnet, Carine Halfon‐Domenech, Judith Diakiesse, Kokou‐Placide Agbo‐Kpati, Nathalie Ravet, Isabelle Thuret, Sarah Szepetowski, Estelle Jean, Benjamin De Sainte Marie, Benoit Meunier, Benoit Faucher, Matias Muszlak, Abdourahim Chamouine, Alain Garou, Caroline Masserot‐Lureau, Jean‐Marc Schneider, Veronique Dorvaux, Philippe Carassou, Honorat Andriamihaja, Muriel Lalande, Perrine Mahe, Anne Sirvent, Patricia Aguilar Martinez, Ivan Bertchansky, Jean‐Claude Eisenmann, Agathe Masseau, Marie‐Laure Couec, Fanny Rialland, Pierre‐Simon Rohrlich, Sandrine Baron‐Joly, Mohamed Conde, Antoine Dossier, Valentine Brousse, Karima Yakouben, Malika Benkerrou, Ghislaine Ithier, Florence Missud, Jean‐Hugues Dalle, Bérengène Koehl, Laurent Holvoet, Jean‐Antoine Ribeil, Laure Joseph, Marina Cavazzana, Marianne De Montalembert, Benedicte Neven, Despina Moshous, Mélissa Taylor, Slimane Allali, Bruno Varet, Gerard Socie, Alienor Xhaard, Régis Peffault De La Tour, Thierry Leblanc, Nicolas Boissel, Marie Robin, Nathalie Dhedin, Robert Girot, Sarah Mattioni, François Lionnet, Jean Donadieu, Guy Leverger, Sylvie Fasola, Jean‐Benoit Arlet, Corina Manoli, Maryse Etienne‐Julan, Emmanuelle Bernit, Justine Gellen‐Dautremer, Stéphanie Eyssette, Gilles Blondin, Claire Pluchart, Stanislas Nimubona, Jacinthe Bonneau, Sophie Bayart, Sophie Pertuisel, Benedicte Collet, Laurence Detourmignies, Julie Machin, Mathieu Wemeau, Laurence De Tourmigni, Jean‐Pierre Vannier, Bruno Filhon, Cecile Dumesnil, Agnes Lahary, Pascale Schneider, Stéphanie Ngo, Aurore Malric, Maud Schoeny, Claire Berger, Isabelle Guichard, Aurélie Desbree, Jean‐Louis Stephan, Audrey David, Catherine Paillard, Alexandra Salmon, Shanti Ame, Philippe Gestas, Marianne Besnard, Marie‐Pierre Castex, Geneviève Plat‐Wilson, Pierre Cougoul, Marlène Pasquet, Jill Serre, Marion Yvert, Jean‐Baptiste Valentin, Francis Duchene, Suzanne Mathieu, Marie Drouilly, Marie Detrait, Cécile Pochon, Aurélie Phulpin, Sylvie Nathanson +194 morewiley +1 more sourceOral Microbiota: Findings, Classification, Clinical Significance, and Therapeutic Interventions for Human Systemic Diseases
iMetaMed, Volume 2, Issue 1, March 2026.Oral microbiota: findings, classification, clinical significance, and therapeutic interventions for human systemic diseases ABSTRACT
The oral microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms that colonizes the oral cavity.Miao Zhang, Meihang Du, Wenjiang Zhang, Renhuan Huang, Wanting Li, Tongqi Li, Junping Bai, Ning Zhang, Jungang Chen, Jing Zhou, Bing Wang, Liwei An, Hideaki Kagami, Yiming Zhang +13 morewiley +1 more sourceThe alveolar microenvironment of patients infected with human immunodeficiency virus does not modify alveolar macrophage interactions with Streptococcus pneumoniae. [PDF]
, 2013 We tested the hypothesis that HIV infection results in activation of alveolar macrophages and that this might be associated with impaired defense against pneumococcus. We compared alveolar macrophages and lymphocytes in 131 bronchoalveolar lavage samples Pridmore, Alison, Molyneux, Malcolm E, Molyneux, Malcolm E., Jagoe, R Thomas, Gordon, Stephen, Zijlstra, Eduard E, Jarman, Elizabeth R., North, James C., Read, Robert C., French, Neil, Read, Robert C, Gordon, Stephen B., Musaya, Janelisa, North, James C, Gordon, Stephen B, Jarman, Elizabeth R, Jagoe, R. Thomas, Zijlstra, Eduard E. +17 morecore +1 more sourceEpidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru
Revista Peruana de Medicina Experimental y Salud Pública, 2016 Objectives. To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru. Materials and Methods.Long Davalos, Yessica Terrazas, Ana Quintana, Martha Egoavil, Katherine Sedano, María E. Castillo, Isabel Reyes, Eduardo Chaparro, Wilda Silva, Francisco Campos, Andrés Saenz, Roger Hernandez, Olguita del Águila, Daniel Guillén Pinto, Theresa J. Ochoa +14 moredoaj +1 more sourceMeningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency
European Journal of Immunology, Volume 56, Issue 2, February 2026.We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy +9 morewiley +1 more source
