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Epidemiology of Pneumococcal Pneumonia in Louisville, Kentucky, and Its Estimated Burden of Disease in the United States [PDF]
Microorganisms, 2023 Streptococcus pneumoniae remains a primary pathogen in hospitalized patients with community-acquired pneumonia (CAP). The objective of this study was to define the epidemiology of pneumococcal pneumonia in Louisville, Kentucky, and to estimate the burden
Julio Ramirez +12 more
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MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia [PDF]
Cells, 2023 Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when ...
Cengiz Goekeri +18 more
doaj +2 more sources
Neutrophil Recruitment in Pneumococcal Pneumonia [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Streptococcus pneumoniae (Spn) is the primary agent of community-acquired pneumonia. Neutrophils are innate immune cells that are essential for bacterial clearance during pneumococcal pneumonia but can also do harm to host tissue. Neutrophil migration in
Catherine S. Palmer +1 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2020 New diagnostic tests for the etiology of childhood pneumonia are needed. We evaluated the antibody-in-lymphocyte supernatant (ALS) assay to detect immunoglobulin (Ig) G secretion from ex vivo peripheral blood mononuclear cell (PBMC) culture, as a ...
Michael J. Carter +36 more
doaj +1 more source
Journal of Biomedical Science, 2020 Background Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of ...
Ching-Fen Shen +10 more
doaj +1 more source
Clinical and Microbiological Factors Associated with High Nasopharyngeal Pneumococcal Density in Patients with Pneumococcal Pneumonia. [PDF]
PLoS ONE, 2015 We aimed to study if certain clinical and/or microbiological factors are associated with a high nasopharyngeal (NP) density of Streptococcus pneumoniae in pneumococcal pneumonia.
Helena Alpkvist +7 more
doaj +1 more source
Use of procalcitonin and C-reactive protein to evaluate vaccine efficacy against pneumonia. [PDF]
PLoS Medicine, 2005 Pneumonia remains the leading cause of death in young children. The poor specificity of chest radiographs (CXRs) to diagnose pneumococcal pneumonia may underestimate the efficacy of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia.The ...
Shabir A Madhi +3 more
doaj +1 more source
Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. [PDF]
PLoS ONE, 2015 Streptococcus pneumoniae is a leading cause of pneumonia worldwide. However, the burden of pneumococcal pneumonia among adults in low- and middle-income countries is not well described.Data from 2008-2012 was analyzed from two surveillance sites in ...
Carmen Lucía Contreras +9 more
doaj +1 more source
Children, 2022 Despite advances in preventative interventions, invasive pneumococcal disease and pneumonia cause significant morbidity and mortality in children. We studied the annual incidence of pneumococcal-specific and syndromic invasive disease and non-invasive ...
Elisa Barbieri +9 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 The recently published article by Shami et al. describes a cost-effectiveness analysis of sequential pneumococcal vaccination with 13-valent pneumococcal conjugate vaccine (PCV13) followed by 23-valent pneumococcal polysaccharide vaccine (PPSV23 ...
Ulrike K. Buchwald +2 more
doaj +1 more source