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Pneumococcal Infection and Pneumococcal Vaccine
New England Journal of Medicine, 1977The pneumococcus (Streptococcus pneumoniae) is a major cause of pneumonia, otitis media and meningitis throughout the world. Although the mortality resulting from pneumococcal infection has declined strikingly since the introduction of the sulfonamides, penicillin and other antibiotics, what limited epidemiologic evidence is available suggests that the
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Pneumococcal conjugate vaccines
Immunology Letters, 1991We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method. The use of a spacer, 6-aminohexanoic acid, resulted in higher incorporation of carrier protein. Conjugates contained up to 10% free polysaccharide, but no free protein.
Bart L. Haagmans +6 more
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Pediatric Clinics of North America, 2000
Streptococcus pneumoniae or pneumococcus is a major pathogen causing meningitis, pneumonia, other invasive infections, and the common infections acute otitis media and sinusitis. The major virulence factor is the polysaccharide capsule, present as one of approximately 90 serotypes. Anticapsular antibodies protect against infection.
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Streptococcus pneumoniae or pneumococcus is a major pathogen causing meningitis, pneumonia, other invasive infections, and the common infections acute otitis media and sinusitis. The major virulence factor is the polysaccharide capsule, present as one of approximately 90 serotypes. Anticapsular antibodies protect against infection.
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Annals of Internal Medicine, 1986
Excerpt To the editor: In the January issue, Bolan and colleagues (1) describe their analysis of the distribution of pneumococcal serotypes isolated from blood and cerebrospinal fluid of vaccinated...
Philip D. Lief +2 more
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Excerpt To the editor: In the January issue, Bolan and colleagues (1) describe their analysis of the distribution of pneumococcal serotypes isolated from blood and cerebrospinal fluid of vaccinated...
Philip D. Lief +2 more
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Pneumococcal vaccination of children
Seminars in Pediatric Infectious Diseases, 2002Streptococcus pneumoniae is the most frequent cause of invasive bacterial infection in children younger than 2 years of age, reaching a peak incidence at 6 to 12 months of age. Pneumococci also cause many cases of pneumonia, sinusitis, and otitis media.
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Pneumococcal conjugate vaccine
Current Opinion in Pediatrics, 2001Pneumococcal infections account for a significant proportion of bacterial infections in infants and children. The growing threat from pneumococci resistant to penicillin and other antimicrobials has led to increased pressure for the development of an effective vaccine.
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Pneumococcal Infections and Pneumococcal Vaccine: An Update
Infection Control, 1982AbstractPneumococcal pneumonia continues to be an important disease in terms of prevalence, morbidity and mortality. With the discovery of penicillin and its wide clinical use, the overall mortality of pneumococcal pneumonia has been significantly reduced, but problems remain.
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Evaluation of Pneumococcal Vaccine
JAMA: The Journal of the American Medical Association, 1981To the Editor.— Regarding the article entitled "A Cost-Benefit Analysis of Immunization of Pneumococcal Pneumonia" by Patrick and Woolley (1981; 245:473), this analysis and one published previously 1 required estimation of a number of variables, including incidence of vaccine reactions and vaccine-type Streptococcus pneumoniae infections in vaccine ...
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Pneumococcal vaccination in adults
Current Infectious Disease Reports, 2005Pneumococci remain the most common etiology of community-acquired pneumonia in adults, with significant attendant mortality in the elderly. With the recognition of increasing rates of drug-resistant Streptococcus pneumoniae in recent years, efforts to prevent disease through vaccination have gained greater impetus. The 23-valent pneumococcal vaccine is
Tsering Y. Sherpa, Howard L. Leaf
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Pneumococcal Vaccination in Diabetes
JAMA: The Journal of the American Medical Association, 1981To the Editor.— The COMMENTARY by James M. Moss, MD (1980;243:2301), entitled "Pneumococcus Infection in Diabetes Mellitus: Is This a Justification for Immunization?" concluded that diabetes is not a valid indication for pneumococcal vaccination because excess risk for development of the disease among diabetics has not been established. I do not think
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