Results 51 to 60 of about 24,278 (218)

Treatment of Severe Adenovirus Infection With HAdV‐B21 in a Young Obese Male With Normal Immunity

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Adenovirus infections are usually mild, but rare serotypes like “HAdV‐B21” can cause severe pneumonia even in healthy individuals. We report a 32‐year‐old immunocompetent obese male who developed life‐threatening HAdV‐B21 pneumonia (PaO2/FiO2 62 mmHg), requiring mechanical ventilation.
Ji Peng, Zhen Wang, Shili Zhong
wiley   +1 more source

A New Name for Pneumocystis from Humans and New Perspectives on the Host-Pathogen Relationship

Emerging Infectious Diseases, 2002
The disease known as Pneumocystis carinii pneumonia (PCP) is a major cause of illness and death in persons with impaired immune systems. While the genus Pneumocystis has been known to science for nearly a century, understanding of its members remained ...
James R. Stringer, Charles B. Beard, Robert F. Miller, Ann E. Wakefield   +3 more
doaj   +1 more source

Comparative genomics suggests that the human pathogenic fungus Pneumocystis jirovecii acquired obligate biotrophy through gene loss. [PDF]

, 2014
Pneumocystis jirovecii is a fungal parasite that colonizes specifically humans and turns into an opportunistic pathogen in immunodeficient individuals. The fungus is able to reproduce extracellularly in host lungs without eliciting massive cellular death.
Cissé, O.H., Hauser, P.M., Pagni, M.
core   +1 more source

Machine Learning Algorithms for Adverse Drug Reactions Prediction and Identifying Its Determinants Among HIV Patients on Antiretroviral Therapy in the University of Gondar Comprehensive and Specialized Hospital, in Amhara Region, Ethiopia

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background Harmful and unexpected reactions to drugs given at standard dosages using the appropriate administration technique for the goals of therapy, diagnosis, or prevention are known as adverse drug reactions (ADRs). Every medicine has the potential to produce both favorable and unfavorable outcomes.
Mequanente Dagnaw, Addis Belayneh
wiley   +1 more source

Adjunctive Corticosteroid Therapy Decreases Lung Permeability in Patients with AIDS-Related Pneumocystis carinii Pneumonia

Canadian Respiratory Journal, 1995
OBJECTIVE: To assess the effect of adjunctive corticosteroid therapy on lung permeability as measured by Tc-DTPA lung clearance scan in patients with AIDS-related Pneumocystis carinii pneumonia (PCP).
Silvia Guillemi, Allan Belzberg, Lindsay M Lawson, Martin T Schechter, Julio SG Montaner   +4 more
doaj   +1 more source

A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin

Journal of General and Family Medicine, Volume 26, Issue 5, Page 479-484, September 2025.
We report a case of agranulocytosis caused by sulbactam/ampicillin. During antimicrobial therapy, close monitoring of total white blood cell counts is essential. Abstract Idiosyncratic drug‐induced agranulocytosis is a rare but life‐threatening condition that requires immediate medical intervention.
Kazuya Toda, Kaku Kuroda, Moe Kuroda, Kota Kawai, Yukihiro Sato   +4 more
wiley   +1 more source

Association between a Specific Pneumocystis jiroveci Dihydropteroate Synthase Mutation and Failure of Pyrimethamine/Sulfadoxine Prophylaxis in Human Immunodeficiency Virus-Positive and -Negative Patients [PDF]

, 2017
To investigate the possible association between different prophylactic sulfa drugs and the genotype of the Pneumocystis jiroveci dihydropteroate synthase (DHPS) gene, we examined DHPS polymorphisms in clinical specimens from 158 immunosuppressed patients
Bille, Jacques, Francioli, Patrick, Hauser, Philippe M., Meneau, Isabelle, Nahimana, Aimable, Rabodonirina, Meja, Zanetti, Giorgio   +6 more
core  

Caspofungin Combined With TMP/SMZ in Treatment of Intractable Acute Pneumocystis jirovecii Pneumonia in Renal Transplant Recipients: Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) is a potential life‐threatening opportunistic infection that predominantly affects immunocompromised individuals, such as those with human immunodeficiency virus or organ transplant recipients. The treatment of PJP, particularly severe cases, remains challenging, as standardized treatment therapies often ...
Hongtao Hu, Shen Xu, Wen Jiang, Baoping Xu, Jing Wang, Gang Xu   +5 more
wiley   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, Volume 45, Issue 8, Page 1455-1475, August 2025.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

Genetic Variation in Pneumocystis carinii Isolates from Different Geographic Regions: Implications for Transmission

Emerging Infectious Diseases, 2000
To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S.
Charles B. Beard, Jane L. Carter, Scott P. Keely, Laurence Huang, Norman J. Pieniazek, Iaci N.S. Moura, Jacquelin M. Roberts, Allen W. Hightower, Michelle S. Bens, Amanda R. Freeman, Sherline Lee, James R. Stringer, Jeffrey S. Duchin, Carlos Del Rio, David Rimland, Robert P. Baughman, Deborah A. Levy, Vance J. Dietz, Paul Simon, Thomas R. Navin   +19 more
doaj   +1 more source