Results 61 to 70 of about 675 (97)

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

Palivizumab for Donor‐Derived RSV Infection in an Adult Bilateral Lung Transplant Recipient: A Case Report

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We describe the use of off‐label palivizumab in an early post‐operative bilateral lung transplant recipient with probable donor‐derived RSV who developed persistent severe LRTI and respiratory failure. RSV PCR Ct fell and remained low from day 0 to day 42 despite conventional therapy until palivizumab was administered on day 44, following which we ...
Rosemary Meharry, Cassandra Vale, John Mackintosh   +2 more
wiley   +1 more source

Prevalence of fungal infections in a patient cohort in The Gambia: Identification and characterization of three priority fungal species in patients with symptoms suggestive of TB.

PLoS ONE
Invasive fungal infections are an increasing global health concern, particularly in low-resource settings where diagnostic capacity is limited. In The Gambia, where tuberculosis is highly prevalent, fungal infections may be misdiagnosed as mycobacterial ...
Zackary Salem-Bango, Mary Basiru Njai, Zainab Tambajang, Tessa Rose Cornell, Jayne Sutherland, Karen Forrest, Omai Garner, Behzad Nadjm, Saffiatou Darboe, Basil Sambou, Sheikh Jarju   +10 more
doaj   +1 more source

Evaluation of Global Immune Biomarkers to Predict Infections in Lung Transplant Recipients

Clinical Transplantation, Volume 40, Issue 8, August 2026.
ABSTRACT Background Immune biomarkers could assess levels of immunosuppression and predict infections in transplant recipients. We aimed to evaluate the absolute lymphocyte count (ALC), absolute neutrophil count (ANC), Quantiferon‐Monitor and the mitogen component of the Quantiferon‐CMV assay alone and combined to predict serious opportunistic ...
Quoc Nguyen, Michael J. Lydeamore, Adina Dessauer, Gregory I. Snell, Glen P. Westall, Anton Y. Peleg, Bradley J. Gardiner   +6 more
wiley   +1 more source

Pneumonia in Human Immunodeficiency Virus–infected Adults and Adolescents: Current Concepts and Future Directions

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2015
Pneumocystis jirovecii pneumonia (PCP) is one of the most common opportunistic infections in human immunodeficiency virus–infected adults. Colonization of Pneumocystis is highly prevalent among the general population and could be associated with the ...
Sadatomo Tasaka
doaj   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Risk of urinary tract infection with SGLT2 inhibitor initiation in patients with immune‐mediated inflammatory diseases and type 2 diabetes: A target trial emulation using a Japanese hospital‐based claims database

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1310-1321, August 2026.
In this target trial emulation of patients with immune‐mediated inflammatory diseases and type 2 diabetes, SGLT2 inhibitor initiation was not associated with a clear increase in UTI risk versus metformin, including across immunosuppressive therapy strata.
Hiroshi Tsushima, Nobuyuki Yajima, Takashi Nomiyama, Ryoko Sakai, Hisashi Noma, Akira Katagiri, Naoto Tamura   +6 more
wiley   +1 more source

Management of Kaposiform Haemangioendothelioma—A Retrospective Case Series Examining the Use and Effectiveness of Vincristine

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1450-1457, August 2026.
ABSTRACT Aim Kaposiform haemangioendothelioma is a rare vascular tumour. Management has evolved over the last two decades, with most cases receiving vincristine or sirolimus. We aim to describe our experience with managing this tumour, with a focus on the safety and efficacy of vincristine.
Bronwen Kirk, Susan Adams, Orli Wargon, Artiene Tatian, Susan Russell   +4 more
wiley   +1 more source

Central Nervous System Infections in Pediatric Solid Organ Transplant Recipients

Pediatric Transplantation, Volume 30, Issue 8, August 2026.
CNS infections in SOT recipients are rare and presentation can be subtle. Therefore, a low threshold for evaluation is warranted to minimize the associated mortality. ABSTRACT Background Solid organ transplant (SOT) recipients face an increased risk of central nervous system (CNS) infections due to immunosuppression.
Amna AlSaihati, Kathleen E. Hosek, Cristina Otero, Brandon H. Tran, Carrie A. Mohila, David Moreno McNeill, Mini Michael, Krupa R. Mysore, Joseph A. Spinner, Claire E. Bocchini, Kristen G. Valencia Deray   +10 more
wiley   +1 more source

Slicing through the challenge of maintaining Pneumocystis in the laboratory

mBio
Pneumocystis jirovecii is a major fungal pathogen of humans that causes life-threatening lung infections in immunocompromised individuals. Despite its huge global impact upon human health, our understanding of the pathobiology of this deadly fungus ...
Olga A. Nev, Lucian Duvenage, Alistair J. P. Brown, Rachael Dangarembizi, Jennifer Claire Hoving   +4 more
doaj   +1 more source