Results 1 to 10 of about 206,477 (120)

HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis

Scientific Reports, 2021
SAMHD1, a human host factor found in myeloid cells which restricts HIV-1 replication. It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells.
Ahlam Mohamed, Talal Bakir, Huda Al-Hawel, Ibtihaj Al-Sharif, Razan Bakheet, Lubna Kouser, Valarmathy Murugaiah, Maha Al-Mozaini   +7 more
doaj   +1 more source

Human immunodeficiency virus in Saudi Arabia: Current and future challenges

Journal of Infection and Public Health, 2023
Introduction: Understanding the pathophysiology of HIV infection has been crucial to the design of effective anti-viral strategies. HIV infection is declining worldwide due to early diagnosis and the effective long-term use of anti-retroviral therapy ...
Maha Al-Mozaini, Tahani Al-Rahabani, Qais Dirar, Tala Alashgar, Ali A. Rabaan, Waleed Murad, Jawaher Alotaibi, Abdulrahman Alrajhi   +7 more
doaj   +1 more source

Evaluation of two molecular detection platforms for gastroenteritis pathogens in treated sewage water in the Eastern province of Saudi Arabia

Scientific Reports, 2022
The ability to screen environmental water samples for gastroenteritis pathogens, particularly viruses remains challenging. Here, we investigated the presence of enteric viruses in treated sewage effluent water samples collected from a cooling tower in ...
Fawaz A. Al-Wohaib, Ibtihaj Al-Sharif, Hassan Al-Zain, Donna Murad, Layla Al-Harbi, Maha Al-Mozaini   +5 more
doaj   +1 more source

Implementation of a Routine Screening Program for Latent Tuberculosis Infection among Patients with Acute Leukemia at a Canadian Cancer Center

Current Oncology, 2022
Background: Screening for latent tuberculosis infection (LTBI) in patients with hematological malignancy is recommended because of their increased risk of tuberculosis (TB). We assessed the utility of tuberculin skin test (TST) screening in patients with
Rbab Taha, Sagar Kothari, Farid Foroutan, Melissa Gitman, Vikas Gupta, Tram Nguyen, Coleman Rotstein   +6 more
doaj   +1 more source

New Insights on CMV Management in Solid Organ Transplant Patients: Prevention, Treatment, and Management of Resistant/Refractory Disease

Infectious Diseases and Therapy, 2022
Cytomegalovirus (CMV) infection can have both direct and indirect effects after solid-organ transplantation, with a significant impact on transplant outcomes.
Camille Nelson Kotton, Nassim Kamar
doaj   +1 more source

Mycobacterium tuberculosis Dominance over Nontuberculous Mycobacteria Irrespective of Immune Status: An Indian Scenario

Journal of Medical Microbiology and Infectious Diseases, 2022
Introduction: In HIV-associated tuberculosis cases, identifying nontuberculous Mycobacteria (NTM) from clinical samples has become essential regarding patients’ treatment and prognosis.
Soumya Dasgupta1, Oindrila Chakraborty2
doaj   +1 more source

Real-World Experience of the Comparative Effectiveness and Safety of Combination Therapy with Remdesivir and Monoclonal Antibodies versus Remdesivir Alone for Patients with Mild-to-Moderate COVID-19 and Immunosuppression: A Retrospective Single-Center Study in Aichi, Japan

Viruses, 2023
The coronavirus disease (COVID-19) pandemic continues to threaten global public health. Remdesivir and monoclonal antibodies have shown promise for COVID-19 treatment of patients who are immunocompromised, including those with cancer, transplant ...
Jun Hirai, Nobuaki Mori, Daisuke Sakanashi, Wataru Ohashi, Yuichi Shibata, Nobuhiro Asai, Hideo Kato, Mao Hagihara, Hiroshige Mikamo   +8 more
doaj   +1 more source

Talaromyces amestolkiae Infection in an AIDS Patient with Cryptococcal Meningitis

Journal of Fungi, 2023
Concurrent infections caused by multiple fungal pathogens in immunocompromised patients can pose diagnostic and treatment challenges. Here, we presented the first reported case in Taiwan of an AIDS patient who had concurrent infection with Cryptococcus ...
Li-An Wang, Yu-Chuan Chuang, Ting-Kuang Yeh, Kuan-Pei Lin, Chi-Jan Lin, Po-Yu Liu   +5 more
doaj   +1 more source

A Review on the Impact of the SARS-CoV-2 Omicron Subvariant on Elderly Patients with Diverse Co-Morbidities

Biologics, 2023
The SARS-CoV-2 virus has caused a catastrophic impact on the world for the past 3 years. The virus has now returned with the emergence of the Omicron (B.1.1.529) variant.
Avinash Khadela, Shruti Soni, Kaivalya Megha, Shivam Bhagat, Vivek P. Chavda   +4 more
doaj   +1 more source

Novel Polyomaviruses in Mammals from Multiple Orders and Reassessment of Polyomavirus Evolution and Taxonomy

Viruses, 2019
As the phylogenetic organization of mammalian polyomaviruses is complex and currently incompletely resolved, we aimed at a deeper insight into their evolution by identifying polyomaviruses in host orders and families that have either rarely or not been ...
Bernhard Ehlers, Augustin E. Anoh, Nicole Ben Salem, Sebastian Broll, Emmanuel Couacy-Hymann, Daniela Fischer, Alma Gedvilaite, Nanina Ingenhütt, Sonja Liebmann, Maite Martin, Arsene Mossoun, Lawrence Mugisha, Jean-Jacques Muyembe-Tamfum, Maude Pauly, Bernat Pérez de Val, Hannah Preugschas, Dania Richter, Grit Schubert, Claudia A. Szentiks, Tamara Teichmann, Cornelia Walter, Rainer G. Ulrich, Lidewij Wiersma, Fabian H. Leendertz, Sébastien Calvignac-Spencer   +24 more
doaj   +1 more source