Results 41 to 50 of about 830,607 (295)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Lipoid Pneumonia: Siphoning of Gasoline

Journal of Association of Pulmonologist of Tamil Nadu
Lipoid pneumonia is a rare condition that accounts for 1%–2.5% of all pneumonia. There are two types – exogenous and endogenous. In recent days, exogenous lipoid pneumonia has been on an increasing trend due to the exponential use of vaping.
Keerthi A. Prakash, Aarthi Narasimhan, Riha Mehrin   +2 more
doaj   +1 more source

A Radiologic Overview of Aspiration-Induced Lung Disease in Adults

대한영상의학회지, 2018
Aspiration is defined as accidental entrance of foreign matter into the lower respiratory tract, and is a common event and can occur in healthy individuals.
Eun-Young Kang, Hwan Seok Yong, Cherry Kim, Ki Yeol Lee, Sung Ho Hwang, Yu-Whan Oh   +5 more
doaj   +1 more source

Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine

Chinese Medicine, 2019
Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown.
Lili Lin, Hua Yan, Jiabin Chen, Huihui Xie, Linxiu Peng, Tong Xie, Xia Zhao, Shouchuan Wang, Jinjun Shan   +8 more
doaj   +1 more source

Severe lower respiratory tract infection in early infancy and pneumonia hospitalizations among children, Kenya. [PDF]

, 2013
Severe lower respiratory tract infection (LRTI) in infants caused by respiratory syncytial virus (RSV) has been associated with later pneumonia hospitalization among children.
Eric O. Ohuma, Nokes, D. James, Nokes, DJ, Ngama, Mwanajuma, Ngama, M, Patrick Kiio Munywoki, Bauni, E, Scott, J Anthony G, Ohuma, Eric O., Munywoki, Patrick Kiio, Scott, John, Ohuma, EO, J. Anthony G. Scott, Munywoki, PK, Bauni, Evasius, Mwanajuma Ngama, Scott, J. Anthony G., Nokes, D James, Ohuma, Eric O, Evasius Bauni, D. James Nokes   +20 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

STATINS AND RISK OF INFECTIOUS DISEASES

Рациональная фармакотерапия в кардиологии, 2015
Besides hypolipidemic effect statins demonstrate some not-lipid (pleotropic) ones. Special attention has been paying to statin inducing reduction in bacterial infections incidence and severity, and pneumonia particularly.
O. M. Drapkina, R. N. Shepel'
doaj   +3 more sources

A case report of exogenous lipoid pneumonia associated with avocado/soybean unsaponifiables

BMC Pulmonary Medicine, 2019
Background Exogenous lipoid pneumonia is a rare disease resulting from intra-alveolar accumulation of lipids of mineral, vegetal, or animal origin, that induce a foreign body type of inflammatory reaction in the lungs. Gastroesophageal reflux disease and
Jacques BOUTROS, Marine MUZZONE, Jonathan BENZAQUEN, Michael LEVRAUT, Charles-Hugo MARQUETTE, Fanny ROCHER, Yann DIASCORN, Bernard PADOVANI, Véronique HOFMAN, Sylvie LEROY   +9 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Idiopathic Lipoid Pneumonia: An incidental finding in autopsy specimen

Autopsy and Case Reports, 2020
Lipoid pneumonia is a rare form of pneumonia which was initially described to be caused by inhalation or aspiration of fatty substances. Certain autopsy studies have reported the incidence to be 1.0-2.5%.
Deepshikha Rana, Nidhi Kaushik, Shreya Sadhu, Rajnish Kalra, Rajeev Sen   +4 more
doaj   +1 more source