Results 51 to 60 of about 830,607 (295)

Treating childhood pneumonia in hard-to-reach areas: a model-based comparison of mobile clinics and community-based care. [PDF]

, 2012
BACKGROUND: Where hard-to-access populations (such as those living in insecure areas) lack access to basic health services, relief agencies, donors, and ministries of health face a dilemma in selecting the most effective intervention strategy. This paper
Francesco Checchi, Roberts Bayard, Roberts, Bayard, Pitt, Catherine, Checchi Francesco, Checchi, Francesco, Pitt Catherine, Catherine Pitt, Bayard Roberts   +8 more
core   +2 more sources

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Integrated multi‐omics profiling landscape of organising pneumonia

Clinical and Translational Medicine
Background Organising pneumonia (OP) is one of the most common and lethal diseases in the category of interstitial pneumonia, along with lung cancer.
Ying Tang, Cuilin Chu, Siyuan Bu, Qin Sun, Airan Liu, Jianfeng Xie, Sen Qiao, Lingyan Huang, Hongmei Wang   +8 more
doaj   +1 more source

Role of Lipidomics in Respiratory Tract Infections: A Systematic Review of Emerging Evidence

Microorganisms
Lower respiratory tract infections (LRTIs) remain a major cause of global morbidity and mortality, yet accurate pathogen identification and risk stratification continue to pose clinical challenges.
Vasiliki E. Georgakopoulou, Konstantinos Dodos, Vassiliki C. Pitiriga   +2 more
doaj   +1 more source

Lipid-laden alveolar macrophages and pH monitoring in gastroesophageal reflux-related respiratory symptoms [PDF]

, 2012
Lipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER).
Rosewich, Martin, Rose, Markus A., H. J. Boehles, M. A. Rose, Kitz, Richard, M. Rosewich, Böhles, Hansjosef, R. Kitz   +7 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Whole lung lavage in the setting of exogenous lipoid pneumonia

Respiratory Medicine Case Reports
Introduction: Lipoid pneumonia results from lipid deposition in the lungs, arising either exogenously or endogenously. Exogenous lipoid pneumonia occurs from aspiration or use of oil-based products such as mineral oil or nasal topicals.
Gaurav A. Jategaonkar, John Fanous, Ryan Dunn, Karen Swanson, Michael B. Gotway, Jehad Azar, Henry D. Tazelaar, Ana C. Zamora, Ann M. Rusk   +8 more
doaj   +1 more source

Inhibition of bacterial virulence factors as a method of treating bacterial pneumonia

Zdorovʹe Rebenka, 2018
Incremental increase in the number of antibiotic-resistant bacterial strains in the etiologic structure of pneumonia and reduced potential of antibiotic therapy increase the importance of drugs in the treatment of pneumonia, which are aimed at ...
А.Е. Abaturov, Т.А. Kryuchko
doaj   +1 more source