Results 41 to 50 of about 89,681 (296)

Ventilator-associated pneumonia prevention in the Intensive care unit using Postpyloric tube feeding in China (VIP study): study protocol for a randomized controlled trial

Trials, 2022
Background Ventilator-associated pneumonia is a challenge in critical care and is associated with high mortality and morbidity. Although some consensuses on preventing ventilator-associated pneumonia are reached, it is still somewhat controversial.
Linhui Hu, Kaiyi Peng, Xiangwei Huang, Zheng Wang, Quanzhong Wu, Yumei Xiao, Yating Hou, Yuemei He, Xinjuan Zhou, Chunbo Chen   +9 more
doaj   +1 more source

Impact of Ventilator-Associated Pneumonia on Resource Utilization and Patient Outcome [PDF]

, 2017
Objective: To assess the effect of ventilator-associated pneumonia on resource utilization, morbidity, and mortality. Design: Retrospective matched cohort study based on prospectively collected data.
Borst, François, Chevrolet, Jean-Claude, Eggimann, Philippe, Hugonnet, Stéphane, Maricot, Patrice, Pittet, Didier   +5 more
core  

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Ventilator-associated pneumonia: the influence of bacterial resistance, prescription errors, and de-escalation of antimicrobial therapy on mortality rates

Brazilian Journal of Infectious Diseases, 2016
Ventilator-associated pneumonia is the most prevalent nosocomial infection in intensive care units and is associated with high mortality rates (14–70%).
Ana Carolina Souza-Oliveira, Thúlio Marquez Cunha, Liliane Barbosa da Silva Passos, Gustavo Camargo Lopes, Fabiola Alves Gomes, Denise Von Dolinger de Brito Röder   +5 more
doaj   +1 more source

Critical Care Nursing Interventions and Incidence of Ventilator Associated Pneumonia in the Trauma Population [PDF]

, 2012
Ventilator Associated Pneumonia (VAP) in the Trauma Intensive Care Unit is the most commonly encountered infection in the intensive care unit and can be linked to increased morbidity, increased mortality, increased mechanical ventilation days, increased ...
Moore, Kelli R.
core   +1 more source

Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion : a prospective cohort study [PDF]

, 2011
Introduction: The triggering receptor expressed on myeloid cells-1 (TREM-1) is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion. Methods:
Bingold, Tobias Michael, Pullmann, Barbara, Sartorius, Sven, Geiger, Emanuel Valentin, Marzi, Ingo, Zacharowski, Kai, Wissing, Heimo, Scheller, Bertram   +7 more
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Ventilator-associated Pneumonia: A Study of Patients admitted in Internal Intensive Care Unit of Ali Asghar Hospital, Shiraz [PDF]

, 2011
Introduction: Ventilator-associated pneumonia is defined as a pneumonia occurring in patients within 48 hours or more after intubation with an endotracheal tube or tracheostomy tube and which not present before.
Bahtouee, Mehrzad, Nikfarjam, Ali, Saboori, Sanaz   +2 more
core  

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source