Results 141 to 150 of about 215,510 (299)

The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma

Pediatric Discovery, EarlyView.
ABSTRACT Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first‐line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways.
Tangqiaochu Gan, Zhou Fu, Chao Niu
wiley   +1 more source

Evidence‐based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China

Pediatric Investigation, EarlyView.
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols. Recent years have witnessed substantial progress in clinical
Committee of Pediatrics, China Medical Education Association, Cooperative Group of Asthma, the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, Pediatric Respiratory Work Committee, Society of Pulmonologists, Chinese Medical Doctor Association, Committee of Pediatrics, Chinese Research Hospital Association, Pediatric Professional Committee of the Chinese Non‐public Medical Institutions Association, Professional Committee of Children's Health and Pharmaceutical Research, China Association of Traditional Chinese Medicine, Children's Safe Medication Branch of China News of Drug Information Association, Pediatric Expert Committee of China Primary Health Care Foundation, China International Medical Foundation   +16 more
wiley   +1 more source

The characterization of dysphagia in COVID‐19 rehabilitation patients: An inpatient rehabilitation cohort study

PM&R, EarlyView.
Abstract Background Severe COVID‐19 infection requiring hospitalization is associated with oropharyngeal dysphagia, yet trajectories in the inpatient rehabilitation facility (IRF) setting remain undercharacterized. Objective To investigate the prevalence, risk factors, recovery likelihood, and evolution of dietary requirements of patients with ...
Benjamin K. Petrie, Christopher W. Lewis, Sean Dreyer, Prakash Jayabalan   +3 more
wiley   +1 more source

Guillain–Barre Syndrome With Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplantation

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chin‐Mu Hsu, Ping‐Hsuan Lin, Chia‐Hsuan Chiu, Hui‐Hua Hsiao   +3 more
wiley   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, EarlyView.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source

The Effect on Mortality of Bacterial Co-Infections on Critically Ill Patients with Community-Acquired COVID-19 and Influenza Pneumonia: A Systematic Review

Background: Bacterial co-infections in patients with viral pneumonia might increase mortality. In this study we aimed to evaluate their effect on the mortality of critically ill patients with viral pneumonia. Methods: A systematic search was conducted in
Efrosyni Gerovasileiou, Konstantinos Mantzarlis, Vasileios Vazgiourakis, Efstratios Manoulakas, Konstantina Deskata, Demosthenes Makris, Apostolos A. Menis, George Dimopoulos   +7 more
core   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, EarlyView.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

GLUT1 Deficiency Syndrome with Coexistent Movement Disorder and Anemia

Movement Disorders Clinical Practice, EarlyView.
Sangeetha Yoganathan, Haya S AlFaris, Anika Menetrey, Sayoni Roy Chowdhury, Lindsey Vogt, Jolynn Dickson, Karen Owusu, Pradeep Krishnan, Suvasini Sharma, Liali Aljouda, Reena Pabari, Grace Yoon, Carolina Gorodetsky   +12 more
wiley   +1 more source

Predicting Failure at Initiation of High‐Flow Nasal Oxygen in Patients With COVID‐19: Literature Review, Development and Internal Validation of a Prediction Model

Respirology, EarlyView.
A prediction model was developed for high‐flow nasal oxygen (HFNO) failure in acute hypoxemic patients with COVID‐19 pneumonia using predictors available prior to HFNO initiation. This stable and good‐performing model can assist in clinical decision‐making at a critical point, aiding timely intervention for patients at risk of HFNO failure.
Daphne J. T. Sjauw, Matthijs L. Janssen, Yasemin Türk, Carmen A. T. Reep, Leo Heunks, Sara J. Baart, Evert‐Jan Wils, on behalf of the Dutch HFNO study group, NORMO2 project group, E. J. Wils, H. Endeman, W. Hanselaar, M. L. Janssen, Y. Türk, R. A. S. Hoek, R. Heller, D. P. Boer, J. H. Elderman, A. Dubois, O. Hoiting, J. Holters, M. vd Steen‐Dieperink, L. Heunks, E. J. Wils, S. J. Baart, M. L. Duiverman, L. M. Fleuren, L. C. Urlings‐Strop, J. G. van den Aardweg, D. Weller, C. A. T. Reep, D. J. T. Sjauw   +31 more
wiley   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source